Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

T cell activation requires interactions of T cell antigen receptors and peptides presented by major histocompatibility complex molecules in an adhesive junction between the T cell and antigen-presenting cell (APC). Stable junctions with bull's-eye supramolecular activation clusters have been defined as immunological synapses (IS). These structures maintain T cell-APC interaction and allow directed secretion. T cells can also be activated by asymmetric hemisynapses (HS) that allow migration during signal integration. IS and HS dominate in different stages of T cell priming. Optimal effector functions may also depend upon cyclical use of IS and HS.

Type

Journal article

Journal

Results Probl Cell Differ

Publication Date

2006

Volume

43

Pages

175 - 198

Keywords

Animals, Antigen-Presenting Cells, Autoimmunity, Cell Movement, Humans, Intercellular Junctions, Lymphocyte Activation, Models, Immunological, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes