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Seminal research over the past 20 years has revealed atherosclerosis to be a chronic inflammatory process that shares features with traditional inflammatory diseases including rheumatoid arthritis. More recently, emphasis has been placed on the role of innate immunity in the development and progression of atherosclerosis. In particular, pattern recognition receptors, including Toll-like receptors (TLRs), have been the focus of much attention as modulators of atherogenesis. This review provides an update on the developments in this area of research in the past 2 years, with a specific focus on the current controversies and how these may affect the design of therapeutics. Specifically, we will address the recent evidence that TLRs elicit both protective and detrimental effects in atherosclerosis and the emerging observation that the outcome of TLR signaling is dependent on the agonist and responding cell type.

Original publication

DOI

10.1016/j.tips.2013.09.008

Type

Journal article

Journal

Trends Pharmacol Sci

Publication Date

11/2013

Volume

34

Pages

629 - 636

Keywords

atheroma, inflammation, innate immunity, therapeutic, Animals, Atherosclerosis, Humans, Immunity, Innate, Toll-Like Receptors