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Molecular understanding of osteoarthritis (OA) has greatly increased through careful analysis of tissue samples, preclinical models, and large-scale agnostic "-omic" studies. There is broad acceptance that systemic and biomechanical signals affect multiple tissues of the joint, each of which could potentially be targeted to improve patient outcomes. In this review six experts in different aspects of OA pathogenesis provide their independent view on what they believe to be good tractable approaches to OA target discovery. We conclude that molecular discovery has been high but future transformative studies require a multidisciplinary holistic approach to develop therapeutic strategies with high clinical efficacy.

Original publication

DOI

10.1016/j.cger.2021.11.015

Type

Journal article

Journal

Clin Geriatr Med

Publication Date

05/2022

Volume

38

Pages

193 - 219

Keywords

Aging, Bone, Cartilage, Fibrosis, Inflammation, Osteoarthritis, Pathophysiology, Treatment targets, Humans, Osteoarthritis