Prosthetic joint infection of revision knee replacement: Epidemiology, outcomes and health economic analysis.
Sabah SA., Alvand A., Price AJ.
Peri-prosthetic joint infection remains one of the most devastating complications of knee arthroplasty surgery. As the number of primary knee joint replacements performed in the UK increases the number of PJI case increases. The rate of infection in the UK is around 7.5 per 1000 (0.8%) but there is some evidence to suggest that this figure is increasing. The complications seen following revision surgery for PJI are greater than those seen after primary knee replacement. There is a significant increased mortality risk for patients with PJI , with 5-year survival comparable to some common cancer diagnoses. In addition patient reported outcomes are adversely affected by PJI. The complexity and extended length of the treatment pathway, together with the adverse outcomes noted above, make these interventions a significant burden on patients and the healthcare system and more work is required to understand the cost-effectiveness of surgical intervention.