IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma
Pandey S., Mourcin F., Marchand T., Nayar S., Guirriec M., Pangault C., Monvoisin C., Amé-Thomas P., Guilloton F., Dulong J., Coles M., Fest T., Mottok A., Barone F., Tarte K.
<jats:title>Key Points</jats:title> <jats:p>FL-infiltrating stromal cells overexpress CXCL12, which triggers FL B-cell migration, adhesion, and activation. Polarization into CXCL12hi stroma involves IL-4+ TFH cells, unlike malignant B cells, revealing an indirect protumoral activity of FL-TFH cells.</jats:p>