The research by Hong et al proposes a new model for T cell receptors interactions using data generated with a biomembrane force probe, significantly adding to our knowledge of how immune cells make decisions that impact host defence and autoimmune disease.
“The immune system uses similar proteins as muscle cells to pull on molecules derived from pathogens to help determine if they should attack or stand down. Ideas are evolving quickly and this has been a great opportunity to take stock of where the field is now”, says Professor Michael Dustin.
Professors Dustin and Dushek are experts in immunology and are frequently called upon to offer opinions on new advances in the field.
Media: movie of single molecule engagement in immunological synapse by David Depoil, used to illustrate how T cells use single molecules of pMHC (green) and that the TCR (red) are actively moving in relation to the pMHC, which generates forces.