Research groups
Stephen Sansom
MPhil, DPhil
Associate Professor
- Group Leader in Computational and Single Cell Genomics
Dr Stephen Sansom graduated with a BSc (Hons) in Biochemistry from the University of Dundee in 2001. He then studied Developmental Biology at the University of Cambridge as a member of the Wellcome Trust 4-year PhD programme in Developmental Biology. During PhD and post-doctoral studies with Dr Rick Livesey at the Gurdon Institute Dr Sansom used genomic approaches to generate insights into pattern-specification and cell-fate choices in the mammalian neocortex.
Recognising the potential of computational biology in the era of next-generation-sequencing Dr Sansom joined Professor Chris Ponting's Computational Genomics Analysis and Training (CGAT) program as an MRC Career Development Fellow at the University of Oxford in 2011. It was during this time that he developed a strong interest in immunology through collaborative research with Professor Georg Hollander resulting in publication of the first single-cell genomics analysis of promiscuous gene expression in thymic epithelial cells.
After a brief appointment as a Senior Genomics Fellow in the Ponting group, Dr Sansom joined the Kennedy Institute in 2014 to the lead the Computational Genomics team. Here, in addition to a continuing interest in the mechanisms of central tolerance, he collaborates closely with experimental groups to unlock the potential of genomics and single-cell approaches for understanding inflammatory disorders.
Key publications
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IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation.
Journal article
Corbin AL. et al, (2020), Sci Immunol, 5
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Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Journal article
Aschenbrenner D. et al, (2021), Gut, 70, 1023 - 1036
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Distinct fibroblast subsets drive inflammation and damage in arthritis.
Journal article
Croft AP. et al, (2019), Nature, 570, 246 - 251
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GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis.
Journal article
Regan-Komito D. et al, (2020), Nat Commun, 11
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.
Journal article
Haenseler W. et al, (2017), Stem Cell Reports, 8, 1727 - 1742
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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.
Journal article
Sansom SN. et al, (2014), Genome Res, 24, 1918 - 1931
Recent publications
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Publisher Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications.
Journal article
Dib L. et al, (2023), Nat Cardiovasc Res, 2
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Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications.
Journal article
Dib L. et al, (2023), Nat Cardiovasc Res, 2, 656 - 672
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Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.
Journal article
MacLean AJ. et al, (2022), Immunity, 55, 718 - 733.e8
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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
Journal article
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk None. and COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None., (2022), Cell, 185, 916 - 938.e58
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An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.
Journal article
Peng Y. et al, (2022), Nat Immunol, 23, 50 - 61