Hideaki Nagase
Emeritus Professor
Recent publications
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Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.
Yamamoto K. et al, (2017), Arthritis Rheumatol, 69, 1246 - 1256
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Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
Scilabra SD. et al, (2017), Matrix Biol, 59, 69 - 79
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Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.
Santamaria S. et al, (2017), MAbs, 9, 595 - 602
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MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
Yamamoto K. et al, (2016), Matrix Biol, 56, 57 - 73
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Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
Doherty CM. et al, (2016), J Biol Chem, 291, 22160 - 22172