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Search results (155)

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Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.

Yamamoto K. et al, (2017), Arthritis Rheumatol, 69, 1246 - 1256

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

Scilabra SD. et al, (2017), Matrix Biol, 59, 69 - 79

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.

Santamaria S. et al, (2017), MAbs, 9, 595 - 602

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.

Yamamoto K. et al, (2016), Matrix Biol, 56, 57 - 73

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

Doherty CM. et al, (2016), J Biol Chem, 291, 22160 - 22172

The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer.

Watanabe K. et al, (2016), J Biol Chem, 291, 20891 - 20899

Distinct biological events generated by ECM proteolysis by two homologous collagenases.

Solomonov I. et al, (2016), Proc Natl Acad Sci U S A, 113, 10884 - 10889

BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice.

Watanabe K. et al, (2016), Biochem Biophys Res Commun, 478, 279 - 285

brogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases.

Watanabe K. et al, (2016), Biochem Biophys Res Commun, 478, 154 - 161

personal journey with matrix metalloproteinases.

Nagase H., (2016), Biol Chem, 397, 805 - 813

nti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro.

Imada K. et al, (2016), Biochem Biophys Res Commun, 476, 352 - 358

Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

Ismail HM. et al, (2016), Arthritis Rheumatol, 68, 1165 - 1171

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.

Poulet B. et al, (2016), PLoS One, 11

ntibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).

Santamaria S. et al, (2015), Biochem J, 471, 391 - 401

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.

Ismail HM. et al, (2015), Arthritis Rheumatol, 67, 1826 - 1836

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