Alex Clarke
PhD FRCP
Wellcome Trust Clinical Research Career Development Fellow
- Senior Clinical Research Fellow
- Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre
I qualified in Medicine from UCL in 2001, and trained in Rheumatology in London. Supported by a Wellcome Trust Clinical Research Training Fellowship, I completed a PhD on the role of autophagy in lupus in 2013, supervised by Tim Vyse at King’s College London.
After completing my medical specialist training, I moved to Oxford to join the group of Katja Simon at the Weatherall Institute of Molecular Medicine as a postdoctoral clinical fellow in 2014, again supported by the Wellcome Trust.
In 2018 I was awarded a Wellcome Trust Clinical Research Career Development Fellowship, establishing my own group here at the Kennedy Institute of Rheumatology.
Key publications
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Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.
Journal article
Clarke AJ. et al, (2015), Ann Rheum Dis, 74, 912 - 920
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Autophagy in the renewal, differentiation and homeostasis of immune cells.
Journal article
Clarke AJ. and Simon AK., (2019), Nat Rev Immunol, 19, 170 - 183
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B1a B cells require autophagy for metabolic homeostasis and self-renewal.
Journal article
Clarke AJ. et al, (2018), J Exp Med, 215, 399 - 413
Recent publications
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B Cell Metabolism and Autophagy in Autoimmunity
Journal article
Raza IGA. and Clarke AJ., (2021), Frontiers in Immunology, 12
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EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells.
Journal article
Roy S. et al, (2021), Nat Commun, 12
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One carbon (metabolism) to rule T cell identity
Journal article
Richter FC. and Clarke AJ., (2021), Nature Reviews Immunology
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Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus.
Journal article
Bolton C. et al, (2020), Drugs R D, 20, 319 - 330
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Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.
Journal article
Odhams CA. et al, (2019), Nat Commun, 10