Alex Clarke

PhD MRCP

Wellcome Trust Clinical Research Career Development Fellow

Senior Clinical Research Fellow
Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre

I qualified in Medicine from UCL in 2001, and trained in Rheumatology in London. Supported by a Wellcome Trust Clinical Research Training Fellowship, I completed a PhD on the role of autophagy in lupus in 2013, supervised by Tim Vyse at King’s College London.

After completing my medical specialist training, I moved to Oxford to join the group of Katja Simon at the Weatherall Institute of Molecular Medicine as a postdoctoral clinical fellow in 2014, again supported by the Wellcome Trust.

In 2018 I was awarded a Wellcome Trust Clinical Research Career Development Fellowship, establishing my own group here at the Kennedy Institute of Rheumatology.

Key publications

Autophagy in the renewal, differentiation and homeostasis of immune cells.
Journal article

Clarke AJ. and Simon AK., (2019), Nat Rev Immunol, 19, 170 - 183

Recent publications

Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.
Journal article

Odhams CA. et al, (2019), Nat Commun, 10
Autophagy in the renewal, differentiation and homeostasis of immune cells.
Journal article

Clarke AJ. and Simon AK., (2019), Nat Rev Immunol, 19, 170 - 183
B1a B cells require autophagy for metabolic homeostasis and self-renewal.
Journal article

Clarke AJ. et al, (2018), J Exp Med, 215, 399 - 413
B1a B cells require autophagy for metabolic homeostasis and self-renewal
Working paper

Clarke A. et al, (2017)
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.
Journal article

Riffelmacher T. et al, (2017), Immunity, 47, 466 - 480.e5

More publications