Alex Clarke

PhD MRCP

Wellcome Trust Clinical Research Career Development Fellow

Senior Clinical Research Fellow
Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre

I qualified in Medicine from UCL in 2001, and trained in Rheumatology in London. Supported by a Wellcome Trust Clinical Research Training Fellowship, I completed a PhD on the role of autophagy in lupus in 2013, supervised by Tim Vyse at King’s College London.

After completing my medical specialist training, I moved to Oxford to join the group of Katja Simon at the Weatherall Institute of Molecular Medicine as a postdoctoral clinical fellow in 2014, again supported by the Wellcome Trust.

In 2018 I was awarded a Wellcome Trust Clinical Research Career Development Fellowship, establishing my own group here at the Kennedy Institute of Rheumatology.

Recent publications

B1a B cells require autophagy for metabolic homeostasis and self-renewal.
Journal article

Clarke AJ. et al, (2018), J Exp Med, 215, 399 - 413
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.
Journal article

Riffelmacher T. et al, (2017), Immunity, 47, 466 - 480.e5
Non-canonical autophagy LAPs lupus.
Journal article

Simon AK. and Clarke AJ., (2016), Cell Death Differ, 23, 1267 - 1268
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.
Journal article

Clarke AJ. et al, (2015), Ann Rheum Dis, 74, 912 - 920
A cross-sectional audit of the uptake of seasonal and H1N1 influenza vaccination amongst patients with rheumatoid arthritis in a London hospital.
Journal article

Clarke AJ. et al, (2011), Clin Exp Rheumatol, 29

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