Contact information
Research groups
Alex Clarke
PhD FRCP
Associate Professor and Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre
- Associate Professor
- Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre
I qualified in Medicine from UCL in 2001, and trained in Rheumatology in London. Supported by a Wellcome Trust Clinical Research Training Fellowship, I completed a PhD on the role of autophagy in lupus in 2013, supervised by Tim Vyse at King’s College London.
After completing my medical specialist training, I moved to Oxford to join the group of Katja Simon at the Weatherall Institute of Molecular Medicine as a postdoctoral clinical fellow in 2014, again supported by the Wellcome Trust.
In 2018 I was awarded a Wellcome Trust Clinical Research Career Development Fellowship, establishing my own group here at the Kennedy Institute of Rheumatology.
Key publications
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Asparagine availability controls germinal center B cell homeostasis.
Journal article
Yazicioglu YF. et al, (2024), Sci Immunol, 9
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Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis.
Journal article
Yazicioglu YF. et al, (2023), Nat Immunol
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Autophagy in the renewal, differentiation and homeostasis of immune cells.
Journal article
Clarke AJ. and Simon AK., (2019), Nat Rev Immunol, 19, 170 - 183
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B1a B cells require autophagy for metabolic homeostasis and self-renewal.
Journal article
Clarke AJ. et al, (2018), J Exp Med, 215, 399 - 413
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Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.
Journal article
Clarke AJ. et al, (2015), Ann Rheum Dis, 74, 912 - 920
Recent publications
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Metabolomics data for 'Glycogen synthase kinase-3 is essential for Treg development and function'
Dataset
Clarke A., (2025)
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The unusual metabolism of germinal center B cells.
Journal article
Gracie CJ. et al, (2025), Trends Immunol
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Predictive genetic testing for Huntington's disease: Exploring participant experiences of uncertainty and ambivalence between clinic appointments.
Journal article
Ballard LM. et al, (2025), J Genet Couns, 34
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Asparagine availability controls germinal center B cell homeostasis.
Journal article
Yazicioglu YF. et al, (2024), Sci Immunol, 9
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Fuelling B cells: dynamic regulation of B cell metabolism
Journal article
Johnstone JC. et al, (2024), Current Opinion in Immunology, 91, 102484 - 102484