Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Publications

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.

Yamamoto K. et al, (2017), Arthritis Rheumatol, 69, 1246 - 1256

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

Scilabra SD. et al, (2017), Matrix Biol, 59, 69 - 79

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.

Santamaria S. et al, (2017), MAbs, 9, 595 - 602

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.

Yamamoto K. et al, (2016), Matrix Biol, 56, 57 - 73

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

Doherty CM. et al, (2016), J Biol Chem, 291, 22160 - 22172

The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer.

Watanabe K. et al, (2016), J Biol Chem, 291, 20891 - 20899

Distinct biological events generated by ECM proteolysis by two homologous collagenases.

Solomonov I. et al, (2016), Proc Natl Acad Sci U S A, 113, 10884 - 10889

Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases.

Watanabe K. et al, (2016), Biochem Biophys Res Commun, 478, 154 - 161

BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice.

Watanabe K. et al, (2016), Biochem Biophys Res Commun, 478, 279 - 285

A personal journey with matrix metalloproteinases.

Nagase H., (2016), Biol Chem, 397, 805 - 813

Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro.

Imada K. et al, (2016), Biochem Biophys Res Commun, 476, 352 - 358

Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

Ismail HM. et al, (2016), Arthritis Rheumatol, 68, 1165 - 1171

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.

Poulet B. et al, (2016), PLoS One, 11

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).

Santamaria S. et al, (2015), Biochem J, 471, 391 - 401

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.

Ismail HM. et al, (2015), Arthritis Rheumatol, 67, 1826 - 1836

YAP is essential for tissue tension to ensure vertebrate 3D body shape.

Porazinski S. et al, (2015), Nature, 521, 217 - 221

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

Gardiner MD. et al, (2015), Osteoarthritis Cartilage, 23, 616 - 628

DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.

Hu H-Y. et al, (2015), Bioconjug Chem, 26, 383 - 388

Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.

Lund J. et al, (2015), J Biol Chem, 290, 6620 - 6629

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.

Kelwick R. et al, (2015), Int J Cancer, 136, E14 - E26

Load More

1
2
3
4
5
6
7
...
»

Include forthcoming?