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Rheumatoid arthritis is common and leads to joint damage due to persistent synovitis. Aggressive treatment within the first few years after symptom onset, with either disease-modifying antirheumatic drugs or antitumor necrosis factor therapy, reduces the rate of disease progression. There is increasing interest in the concept that the first few months after symptom onset represent a pathologically distinct phase of disease and that this translates into a therap eutic window of opportunity during which it may be possible to switch off the disease process. The rationale for, and difficulties associated with, treatment within this window are discussed. © 2005 Future Drugs Ltd.

Original publication

DOI

10.1586/14750708.2.4.659

Type

Journal article

Journal

Therapy

Publication Date

01/07/2005

Volume

2

Pages

659 - 668