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After assessment in mice, a biological skin equivalent consisting of cultured fibroblasts in a collagen gel overlain with cultured keratinocytes was applied to three patients who had had tattoos excised. In all patients the grafts took well with good cosmetic results and little or no contracture. A biopsy at 4 weeks showed that the central graft area had a fully differentiated epidermis and a mature dermis without adnexae.

Type

Journal article

Journal

Lancet

Publication Date

22/07/1989

Volume

2

Pages

191 - 193

Keywords

Adult, Animals, Culture Techniques, Female, Fibroblasts, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Skin, Skin Transplantation, Tattooing