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Histone lysine methylation is regulated by Nε-methyltransferases, demethylases, and Nε-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigenetic protein classes with synthetic histone substrates containing l- and d-lysine residues. The results reveal that out of the three classes, Nε-methyl lysine binding proteins are superior in accepting lysines with the d-configuration.

Original publication

DOI

10.1039/c7cc08028j

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

12/12/2017

Volume

53

Pages

13264 - 13267

Keywords

Biocatalysis, Epigenesis, Genetic, Histone Demethylases, Lysine, Methylation, Methyltransferases, Models, Molecular, Molecular Conformation, Stereoisomerism, Thermodynamics