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Macrophages are important tissue resident cells that regulate the dynamics of inflammation. However, they are strikingly heterogeneous. During studies looking at podoplanin (gp38) expression on stromal cells in the murine spleen and peritoneal cavity we unexpectedly discovered that podoplanin was expressed on a subset of F4/80(+) macrophages; a subset which we have termed fibroblastic macrophages (FM). These cells function as phagocytes in vitro as measured by bead mediated phagocytosis assays. FM also exist at high frequency in the peritoneal cavity and in zymosan induced peritonitis in vivo. These FM represent a unique subgroup of F4/80(+) macrophages and their presence in the inflamed peritoneum suggests that they play a role in zymosan induced peritonitis.

Original publication

DOI

10.1016/j.febslet.2010.07.053

Type

Journal article

Journal

FEBS Lett

Publication Date

24/09/2010

Volume

584

Pages

3955 - 3961

Keywords

Animals, Fibroblasts, Macrophages, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Peritonitis, Phagocytes, Phagocytosis, Zymosan