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Assembly of the ASC speck is critical for signaling by the inflammasome. In this issue, Kuri et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703103) use live microscopy to track fluorescently tagged endogenous ASC in the zebrafish, describing the molecular domains driving ASC speck assembly and identifying a key role for macrophages in ASC speck removal in vivo.

Original publication

DOI

10.1083/jcb.201708002

Type

Journal article

Journal

J Cell Biol

Publication Date

04/09/2017

Volume

216

Pages

2615 - 2618