Zebrafish earns its stripes for in vivo ASC speck dynamics.
Bezbradica JS., Schroder K.
Assembly of the ASC speck is critical for signaling by the inflammasome. In this issue, Kuri et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201703103) use live microscopy to track fluorescently tagged endogenous ASC in the zebrafish, describing the molecular domains driving ASC speck assembly and identifying a key role for macrophages in ASC speck removal in vivo.