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Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emulate these cytoskeletal forces and trigger T cell activation.

Original publication

DOI

10.1083/jcb.201605072

Type

Journal article

Journal

J Cell Biol

Publication Date

06/06/2016

Volume

213

Pages

501 - 503

Keywords

Animals, Humans, Lymphocyte Activation, Microscopy, Atomic Force, Models, Biological, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes