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Phagocytosis is key for many organismal functions. In a recent issue of Cell, Freeman et al. (2016) demonstrate a feed-forward signaling mechanism wherein F-actin and integrin receptors drive contact formation between phagocytes and antibody-coated solid particles, signaling their engulfment. This mechanism translates nanoscale proximity effects into wider self-propagating signals.

Original publication

DOI

10.1016/j.devcel.2016.01.004

Type

Journal article

Journal

Dev Cell

Publication Date

25/01/2016

Volume

36

Pages

131 - 132

Keywords

Actin Cytoskeleton, Actins, Animals, Humans, Integrins, Phagocytes, Phagocytosis, Signal Transduction