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This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.

Original publication

DOI

10.1098/rspb.2014.3085

Type

Journal article

Journal

Proc Biol Sci

Publication Date

22/12/2015

Volume

282

Keywords

adaptive immunity, infections, innate immunity, Adaptive Immunity, Aging, Autoimmune Diseases, Biological Evolution, Communicable Diseases, Female, Humans, Immune System, Immunity, Innate, Neoplasms, Pregnancy