Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Natural killer (NK) cells destroy virus-infected and tumour cells, apparently without the need for previous antigen stimulation. In part, target cells are recognized by their diminished expression of major histocompatibility complex (MHC) class I molecules, which normally interact with inhibitory receptors on the NK cell surface. NK cells also express triggering receptors that are specific for non-MHC ligands; but the nature of the ligands recognized on target cells is undefined. NKp46 is thought to be the main activating receptor for human NK cells. Here we show that a soluble NKp46-immunoglobulin fusion protein binds to both the haemagglutinin of influenza virus and the haemagglutinin-neuraminidase of parainfluenza virus. In a substantial subset of NK cells, recognition by NKp46 is required to lyse cells expressing the corresponding viral glycoproteins. The binding requires the sialylation of NKp46 oligosaccharides, which is consistent with the known sialic binding capacity of the viral glycoproteins. These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein.

Original publication

DOI

10.1038/35059110

Type

Journal article

Journal

Nature

Publication Date

22/02/2001

Volume

409

Pages

1055 - 1060

Keywords

Animals, Cell Line, Transformed, Cytotoxicity, Immunologic, HN Protein, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunoglobulin Fc Fragments, Killer Cells, Natural, Ligands, Mice, Mice, Inbred BALB C, N-Acetylneuraminic Acid, Natural Cytotoxicity Triggering Receptor 1, Orthomyxoviridae, Protein Binding, Receptors, IgG, Receptors, Immunologic, Recombinant Fusion Proteins, Respirovirus, Transfection, Tumor Cells, Cultured