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Naïve T cell activation requires the interactions of antigen receptors, adhesion molecules and co-stimulatory molecules. Antigen receptors and adhesion molecules are involved in spatio-temporal movement to form a stable immunological synapse. This stable junction interrupts T cell migration, and provides a platform for temporally regulated co-stimulatory receptor signaling spanning a period of days.

Type

Journal article

Journal

Curr Opin Cell Biol

Publication Date

10/2002

Volume

14

Pages

575 - 580

Keywords

Animals, Cell Adhesion, Cell Differentiation, Cell Division, Cell Movement, Humans, Lymph Nodes, Lymphocyte Activation, Signal Transduction, Synapses, T-Lymphocytes, Time Factors