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The immunological synapse (IS) has proved to be a stimulating concept, particularly in provoking discussion on the similarity of intercellular communication controlling disparate biological processes. Recent studies have clarified some of the underlying molecular mechanisms and functions of the IS. For both T cells and natural killer (NK) cells, assembly of the IS can be described in stages with distinct cytoskeletal requirements. Functions of the IS vary with circumstance and include directing secretion and integrating positive and negative signals to determine the extent of response.

Original publication

DOI

10.1016/j.it.2004.03.007

Type

Journal article

Journal

Trends Immunol

Publication Date

06/2004

Volume

25

Pages

323 - 327

Keywords

Animals, Antigen-Presenting Cells, Cell Communication, Humans, Intercellular Junctions, Killer Cells, Natural, Models, Immunological, Receptors, Antigen, T-Cell, Receptors, Immunologic, Signal Transduction, T-Lymphocytes