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Dendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation of an immunological synapse. The structure of the T cell-DC immunological synapse departs from the canonical structure formed with B cells or with supported planar bilayers in that it has multiple foci of T-cell receptor interactions rather than a central focus. Recent studies on model systems provide insight into the mechanisms and biological consequences of the unique T cell-DC synaptic patterns.

Original publication

DOI

10.1016/j.coi.2006.05.017

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

08/2006

Volume

18

Pages

512 - 516

Keywords

Animals, Cell Communication, Cell Membrane, Dendritic Cells, Humans, Lipid Bilayers, T-Lymphocytes