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Dendritic cells prepared by a modification of the method of Steinman and Cohn are I-A+ and FcR-. They are extremely potent at activating not only allogeneic T cell proliferation but also antigen-specific syngeneic T cell proliferation. Dendritic cells from nonresponder strains are unable to present antigens to responder X nonresponder T cells, suggesting that they may be a site of Ir gene product expression.


Journal article


J Exp Med

Publication Date





1817 - 1822


Animals, Antigens, Cell Separation, Genes, MHC Class II, Histocompatibility Antigens Class II, Lymph Nodes, Lymphocyte Activation, Mice, Spleen, T-Lymphocytes