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The lipid sphingosine-1-phosphate has been identified as a key exit signal for lymph nodes. In this issue of Immunity, Pham et al. (2008) show that its action can only be understood in the context of retention signals transduced by CCR7.

Original publication

DOI

10.1016/j.immuni.2008.01.001

Type

Journal article

Journal

Immunity

Publication Date

01/2008

Volume

28

Pages

15 - 17

Keywords

Animals, Chemotaxis, Leukocyte, Lymph Nodes, Lysophospholipids, Receptors, CCR7, Sphingosine, T-Lymphocytes