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The development of effective new treatments is greatly facilitated by the understanding of the mechanisms of disease. In rheumatoid arthritis, there has been progress in understanding its immunology, the HLA class II predisposition including the 'shared epitope' and more recently in understanding the importance of proinflammatory cytokines. Here we review our work in defining TNFalpha as a therapeutic target in rheumatoid arthritis, from an understanding of molecular pathogenesis in vitro, to formal proof in the clinic in vivo. There is now extensive clinical use of anti-TNFalpha biologicals for severe rheumatoid arthritis in the US and Europe.

Type

Journal article

Journal

Joint Bone Spine

Publication Date

01/2002

Volume

69

Pages

12 - 18

Keywords

Antibodies, Monoclonal, Antirheumatic Agents, Arthritis, Rheumatoid, Clinical Trials as Topic, Drug Evaluation, Preclinical, Humans, Infliximab, Treatment Outcome, Tumor Necrosis Factor-alpha