Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A team from the Medical Sciences Division has received a share of $14 million in funding from the Chan Zuckerberg Initiative (CZI). Prof. Mark Coles from the Kennedy Institute of Rheumatology, Dr. Calliope Dendrou, and Dr. Anita Milicic were announced as one of 29 interdisciplinary teams that will explore emerging ideas regarding the role of inflammation in disease.

While inflammation is a natural defense that helps our bodies maintain a healthy state, chronic inflammation results in harmful diseases such as asthma, arthritis, and heart disease, and can also play a role in organ failure, neurodegenerative diseases like Alzheimer's, and many other conditions such as COVID-19.

The CZI welcomed 80 researchers to work on the two-year pilot projects, 75 percent of which are led by early-career scientists within six years of starting their independent position. Grantee teams are made up of two to three investigators with distinct areas of expertise and they represent 11 countries. 

The Oxford investigators will use a range of adjuvants to determine the first steps in the initiation of an inflammatory immune response that can protect against infection.

"Understanding the cellular and molecular basis of adjuvant mediated inflammation in humans is essential to developing the next generation of vaccines and complements ongoing work on the Human Cell Atlas project in the groups of Dr. Calliope Dendrou (Wellcome Trust Centre for Human Genetics) and my group at the Kennedy Institute, and the development of next generation human vaccine adjuvants in Dr. Anita Milicic group (Jenner Institute)," said Mark.

"Knowing more about inflammation at the level of affected cells and tissues will increase our understanding of many diseases and improve our ability to cure, prevent, or manage them," said CZI Head of Science Cori Bargmann. "We look forward to collaborating with these interdisciplinary teams of researchers studying inflammation."

The Chan Zuckerberg Initiative (CZI) was founded by Dr. Priscilla Chan and Mark Zuckerberg in 2015, to leverage technology to help solve some of the world's toughest challenges. These grants build on CZI's work in single-cell biology supporting the Human Cell Atlas, a fundamental reference for health and disease.

Similar stories

Wellcome Trust Investigator Award for Professor Arnon

Congratulations to Professor Arnon on her successful Wellcome Trust Investigator Award entitled: “Spatiotemporal basis of adaptive immunity in the spleen.”

Oxford researchers awarded funding to study the immune response to malaria

Professors Matthew Higgins and Michael Dustin from the University of Oxford, Prof Gavin Wright from the University of York, and Professors Shiroh Iwanaga and Hisashi Arase from Osaka University have secured a Wellcome Collaborative Award for their study “How do RIFINs and STEVORs modulate human immunity during malaria?”

New funding awarded to study persistent pain in inflammatory arthritis

The £3.9M Wellcome Collaborative Award will be used to identify the drivers of pain in people living with rheumatoid arthritis.

Single-cell ancestry vaccine research funded by the Chan Zuckerberg Initiative

The Chan Zuckerberg Initiative (CZI) has provided $2 million in funding to investigate how our ancestry and diversity influence the way that vaccines work in our cells.

Novo Nordisk Postdoctoral Research Fellowship awarded to Inhye Park

Inhye Park has been awarded a Novo Nordisk Postdoctoral Research Fellowship to research the biology of resident vascular macrophages in atherosclerosis.

Researchers from the Kennedy Institute awarded MRC funding

Tonia Vincent, Jelena Bezbradica and Alex Clarke have been awarded funding grants by the Medical Research Council (MRC) for different projects.