Fiona McCann
PhD
Leader for Translational Research Group
Having gained a PhD in Biochemistry in 2001 from the University of Kent, Fiona joined Imperial College London as a postdoc working with Prof. Dan Davis studying the spatiotemporal localization of proteins at the human Natural Killer immune synapse to determine functional outcomes of NK cell surveillance. She then joined Dr. Richard Williams' lab at the Kennedy Institute in 2006 to study translational immunology using experimental models of rheumatoid arthritis. Specifically, she was the first to identify novel immunoregulatory functions of TNFR2 expressing regulatory T cells in murine arthritis. In 2012, she was appointed to the role of project leader for the Novo Nordisk-KIR clinical research satellite, working on target validation and mechanism of action studies in rheumatoid arthritis. Since March 2015, she has been group leader for the ULTRA-DD consortium (IMI funded research initiative) at the KIR in collaboration with the Structural Genomics Consortium, which aims to study epigenetic modifications in both Dupuytren's disease (with Prof. Jagdeep Nanchahal) and Spondyloarthritis patients (with Prof. Paul Bowness).
Recent publications
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Author Correction: Cellular census of human fibrosis defines functionally distinct stromal cell types and states.
Journal article
Layton TB. et al, (2020), Nat Commun, 11
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TNF Receptor 2 Signaling Prevents DNA Methylation at the Foxp3 Promoter and Prevents Pathogenic Conversion of Regulatory T Cells
Journal article
McCann F., (2020), Proceedings of the National Academy of Sciences of USA
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Cellular census of human fibrosis defines functionally distinct stromal cell types and states.
Journal article
Layton TB. et al, (2020), Nat Commun, 11
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Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states.
Journal article
Layton TB. et al, (2020), Biol Open, 9
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Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states.
Journal article
Layton TB. et al, (2020), Biol Open