Sir Marc Feldmann FRS

• Macrophage heterogeneity in the context of rheumatoid arthritis.

  Journal article

  Udalova IA. et al, (2016), Nat Rev Rheumatol, 12, 472 - 485

• Anti-TNF Therapy.

  Journal article

  Udalova I. et al, (2016), Microbiol Spectr, 4

• Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

  Journal article

  Cole JE. et al, (2015), Proc Natl Acad Sci U S A, 112, 13033 - 13038

• Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

  Journal article

  Cribbs A. et al, (2015), Ther Adv Musculoskelet Dis, 7, 206 - 219

• Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss.

  Journal article

  Espirito Santo AI. et al, (2015), Biochem Biophys Res Commun, 464, 1145 - 1150

• IRF5 controls both acute and chronic inflammation

  Journal article

  Weiss M. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 11001 - 11006

• Perspectives From Masters in Rheumatology and Autoimmunity: Can We Get Closer to a Cure for Rheumatoid Arthritis?

  Journal article

  Feldmann M. and Maini RN., (2015), Arthritis Rheumatol, 67, 2283 - 2291

• IRF5 controls both acute and chronic inflammation.

  Journal article

  Weiss M. et al, (2015), Proc Natl Acad Sci U S A, 112, 11001 - 11006

• Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.

  Journal article

  Chan JK. et al, (2015), EMBO Mol Med, 7, 547 - 561

• Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

  Journal article

  Terrando N. et al, (2015), Mol Med, 20, 667 - 675

• Preclinical target validation using patient-derived cells.

  Journal article

  Edwards AM. et al, (2015), Nat Rev Drug Discov, 14, 149 - 150

• Anti-TNF therapy: past, present and future.

  Journal article

  Monaco C. et al, (2015), Int Immunol, 27, 55 - 62

• Design and optimisation of bioactive cyclic peptides: generation of a down-regulator of TNF secretion.

  Journal article

  New R. et al, (2014), Molecules, 19, 21529 - 21540

• Discovery and Development of Anti-TNF Therapy: Pillar of a Therapeutic Revolution. Pillar of a Therapeutic Revolution.

  Chapter

  Feldmann M., (2014), Molecular Biology of B Cells: Second Edition, 541 - 547

• Natural killer (NK) cells and gamma delta T-cells differentially modulate Th17-driven disease in ankylosing spondylitis

  Conference paper

  Wythe SE. et al, (2014), IMMUNOLOGY, 143, 162 - 162

• Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

  Journal article

  McCann FE. et al, (2014), Arthritis Rheumatol, 66, 2728 - 2738

• Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

  Journal article

  Nielsen N. et al, (2014), Immunology, 142, 581 - 593

• Reply: To PMID 23784528.

  Journal article

  Schmidt EM. et al, (2014), Arthritis Rheumatol, 66, 1962 - 1963

• TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

  Journal article

  Ruspi G. et al, (2014), Cell Signal, 26, 683 - 690

• OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

  Journal article

  Gwyer Findlay E. et al, (2014), Proc Natl Acad Sci U S A, 111, 2289 - 2294

• A conversation with Marc Feldmann. Interviewed by Ushma S. Neill.

  Journal article

  Feldmann M., (2014), J Clin Invest, 124, 1 - 2

• Anti-tnf therapy: 20 years from our first therapeutic adventure

  Chapter

  Nanchahal J. et al, (2014), Cytokine Frontiers: Regulation of Immune Responses in Health and Disease, 215 - 244

• Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.

  Journal article

  Schmidt EM. et al, (2013), Arthritis Rheum, 65, 2262 - 2273

• Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

  Journal article

  Verjee LS. et al, (2013), Proc Natl Acad Sci U S A, 110, E928 - E937

• RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.

  Journal article

  Gasparini C. et al, (2013), Cytokine, 61, 736 - 740

• TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes.

  Journal article

  Brenner C. et al, (2012), Scand J Immunol, 76, 359 - 370

• Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA.

  Journal article

  Larsen H. et al, (2012), Arthritis Res Ther, 14

• Alarmins: awaiting a clinical response.

  Journal article

  Chan JK. et al, (2012), J Clin Invest, 122, 2711 - 2719

• Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis.

  Journal article

  Raatz Y. et al, (2012), Arthritis Res Ther, 14

• Effective targeting of the tumor microenvironment for cancer therapy.

  Journal article

  Jiang P. et al, (2012), Anticancer Res, 32, 1203 - 1212

• NF-κB as a target for modulating inflammatory responses.

  Journal article

  Gasparini C. and Feldmann M., (2012), Curr Pharm Des, 18, 5735 - 5745

• The TNF/TNF-R family: A gold mine for clinical therapeutic targets?

  Journal article

  Feldmann M., (2011), Advances in Experimental Medicine and Biology, 691, ix - x

• Resolving postoperative neuroinflammation and cognitive decline.

  Journal article

  Terrando N. et al, (2011), Ann Neurol, 70, 986 - 995

• Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

  Journal article

  Beavis PA. et al, (2011), Proc Natl Acad Sci U S A, 108, 16717 - 16722

• Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.

  Journal article

  Andersson AK. et al, (2011), Arthritis Rheum, 63, 2617 - 2629

• IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

  Journal article

  McNamee KE. et al, (2011), Pain, 152, 1838 - 1845

• IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

  Journal article

  Krausgruber T. et al, (2011), Nat Immunol, 12, 231 - 238

• Unexpected protective role for Toll-like receptor 3 in the arterial wall.

  Journal article

  Cole JE. et al, (2011), Proc Natl Acad Sci U S A, 108, 2372 - 2377

• TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells.

  Journal article

  Glass GE. et al, (2011), Proc Natl Acad Sci U S A, 108, 1585 - 1590

• Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade.

  Journal article

  Gompels LL. et al, (2011), Arthritis Res Ther, 13

• Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.

  Journal article

  Turner JJ. et al, (2010), Clin Exp Immunol, 162, 487 - 493

• Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.

  Journal article

  Terrando N. et al, (2010), Proc Natl Acad Sci U S A, 107, 20518 - 20522

• Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis.

  Journal article

  Malik NM. et al, (2010), Rheumatology (Oxford), 49, 1828 - 1839

• IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.

  Journal article

  Smallie T. et al, (2010), J Exp Med, 207, 2081 - 2088

• Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

  Journal article

  Page TH. et al, (2010), J Immunol, 185, 3694 - 3701

• Role of interleukin-1beta in postoperative cognitive dysfunction.

  Journal article

  Cibelli M. et al, (2010), Ann Neurol, 68, 360 - 368

• SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

  Journal article

  Drexler SK. et al, (2010), Arthritis Rheum, 62, 2249 - 2261

• The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity.

  Journal article

  Weng L. et al, (2010), Ann Rheum Dis, 69, 1519 - 1526

• Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

  Journal article

  Feldmann M. and Maini RN., (2010), J Immunol, 185, 791 - 794

• Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.

  Journal article

  Drexler SK. et al, (2010), Scand J Immunol, 71, 393 - 402

• Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.

  Journal article

  McNamee KE. et al, (2010), Pain, 149, 386 - 392

• Directed issue: novel concepts in inflammation.

  Journal article

  Gilroy DW. et al, (2010), Int J Biochem Cell Biol, 42, 480 - 481

• Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis.

  Journal article

  Dobson R. et al, (2010), J Neuroimmunol, 220, 99 - 103

• Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

  Journal article

  McCann FE. et al, (2010), Arthritis Res Ther, 12

• The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.

  Journal article

  Terrando N. et al, (2010), Crit Care, 14

• What have we learnt from targeted anti-TNF therapy?

  Journal article

  Feldmann M. et al, (2010), Ann Rheum Dis, 69 Suppl 1, i97 - i99

• Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.

  Journal article

  Wegner N. et al, (2010), Immunol Rev, 233, 34 - 54

• Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis.

  Journal article

  Monaco C. et al, (2009), Circulation, 120, 2462 - 2469

• Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

  Journal article

  Hillyer P. et al, (2009), Rheumatology (Oxford), 48, 1581 - 1589

• TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

  Journal article

  Kuai J. et al, (2009), Rheumatology (Oxford), 48, 1352 - 1358

• Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.

  Journal article

  Taylor PC. and Feldmann M., (2009), Nat Rev Rheumatol, 5, 578 - 582

• A view from a European medical academic who spends time in the US.

  Journal article

  Feldmann M., (2009), J Clin Invest, 119, 2861 - 2862

• RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

  Journal article

  Gasparini C. et al, (2009), Eur J Immunol, 39, 2215 - 2223

• Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

  Journal article

  Sumariwalla PF. et al, (2009), Rheumatology (Oxford), 48, 32 - 38

• Translating molecular insights in autoimmunity into effective therapy.

  Journal article

  Feldmann M., (2009), Annu Rev Immunol, 27, 1 - 27

• In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.

  Journal article

  Brennan F. and Feldmann M., (2009), Arthritis Res Ther, 11

• Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

  Journal article

  Sacre SM. et al, (2008), J Immunol, 181, 8002 - 8009

• Many cytokines are very useful therapeutic targets in disease.

  Journal article

  Feldmann M., (2008), J Clin Invest, 118, 3533 - 3536

• Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis.

  Journal article

  Sumariwalla PF. et al, (2008), Arthritis Rheum, 58, 3071 - 3080

• Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.

  Journal article

  Inglis JJ. et al, (2008), Arthritis Rheum, 58, 3110 - 3119

• Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

  Journal article

  Raichel L. et al, (2008), Eur J Immunol, 38, 2905 - 2915

• Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.

  Journal article

  Andersson AK. et al, (2008), Scand J Immunol, 68, 103 - 111

• Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.

  Journal article

  Feldmann M. and Maini SR., (2008), Immunol Rev, 223, 7 - 19

• Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

  Journal article

  Williams LM. et al, (2008), Mol Immunol, 45, 2446 - 2454

• CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.

  Journal article

  Simelyte E. et al, (2008), Arthritis Rheum, 58, 1038 - 1043

• Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.

  Journal article

  Brennan FM. et al, (2008), Arthritis Res Ther, 10

• Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

  Journal article

  Jin P. et al, (2008), Arthritis Res Ther, 10

• Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.

  Journal article

  Wales J. et al, (2007), Biochem Soc Trans, 35, 1501 - 1503

• Targeting intracellular signaling: a novel approach to vaccination.

  Journal article

  Wales J. et al, (2007), Expert Rev Vaccines, 6, 971 - 980

• Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.

  Journal article

  Inglis JJ. et al, (2007), Arthritis Rheum, 56, 4015 - 4023

• Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

  Journal article

  Sacre SM. et al, (2007), Ann Rheum Dis, 66 Suppl 3, iii81 - iii86

• Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

  Journal article

  Lundberg AM. et al, (2007), Blood, 110, 3245 - 3252

• The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.

  Journal article

  Inglis JJ. et al, (2007), Rheumatology (Oxford), 46, 1428 - 1432

• Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.

  Journal article

  Williams RO. et al, (2007), Curr Opin Pharmacol, 7, 412 - 417

• Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.

  Journal article

  Sheryanna A. et al, (2007), J Am Soc Nephrol, 18, 1167 - 1179

• Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

  Journal article

  Bondeson J. et al, (2007), J Rheumatol, 34, 523 - 533

• A new JCI conflict-of-interest policy.

  Journal article

  Neill US. et al, (2007), J Clin Invest, 117, 506 - 508

• Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.

  Journal article

  Sacre SM. et al, (2007), J Immunol, 178, 2148 - 2154

• The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.

  Journal article

  Sacre SM. et al, (2007), Am J Pathol, 170, 518 - 525

• The pitfalls in the development of biologic therapy.

  Journal article

  Maini RN. and Feldmann M., (2007), Nat Clin Pract Rheumatol, 3

• Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.

  Journal article

  Edwards CJ. et al, (2007), Mol Med, 13, 40 - 58

• Crystal-ball gazing--the future of immunological research viewed from the cutting edge.

  Journal article

  Brent L. et al, (2007), Clin Exp Immunol, 147, 1 - 10

• Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.

  Journal article

  Tyndall A. et al, (2007), Arthritis Res Ther, 9

• Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.

  Journal article

  Inglis JJ. et al, (2007), Arthritis Res Ther, 9

• Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

  Journal article

  Amos N. et al, (2006), Rheumatology (Oxford), 45, 1201 - 1209

• Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.

  Journal article

  Andreakos E. et al, (2006), Proc Natl Acad Sci U S A, 103, 14459 - 14464

• Cytokines as therapeutics and targets of therapeutics

  Journal article

  Vilček J. and Feldmann M., (2006), Rheumatologia, 20, 65 - 74

• Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.

  Journal article

  Feldmann M. and Pusey CD., (2006), J Am Soc Nephrol, 17, 1243 - 1252

• Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.

  Journal article

  Grosjean J. et al, (2006), Biochem Biophys Res Commun, 340, 984 - 994

• The importance of T cell interactions with macrophages in rheumatoid cytokine production.

  Journal article

  Brennan FM. et al, (2006), Curr Top Microbiol Immunol, 305, 177 - 194

• Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.

  Journal article

  Waterston AM. et al, (2005), Cancer Immunol Immunother, 54, 848 - 857

• The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.

  Journal article

  Andreakos E. et al, (2005), Front Biosci, 10, 2478 - 2488

• Molecular therapeutic targets in rheumatoid arthritis.

  Journal article

  Sacre SM. et al, (2005), Expert Rev Mol Med, 7, 1 - 20

• Design of effective immunotherapy for human autoimmunity.

  Journal article

  Feldmann M. and Steinman L., (2005), Nature, 435, 612 - 619

• Cannabinoids in Models of Chronic Inflammatory Conditions

  Journal article

  Mechoulam R. et al, (2005), Phytochemistry Reviews, 4, 11 - 18

• Anti-TNF therapy: where have we got to in 2005?

  Journal article

  Feldmann M. et al, (2005), J Autoimmun, 25 Suppl, 26 - 28

• A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.

  Journal article

  Campbell J. et al, (2004), J Immunol, 173, 6928 - 6937

• Rheumatoid arthritis: pathogenic mechanisms and therapeutic targets

  Journal article

  Taylor PC. and Feldmann M., (2004), Drug Discovery Today: Disease Mechanisms, 1, 289 - 295

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

  Journal article

  Burstein S. and Zurier RB., (2004), Arthritis Rheum, 50, 4078 - 4079

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al - Reply

  Journal article

  Sumariwalla PF. et al, (2004), ARTHRITIS AND RHEUMATISM, 50, 4079 - 4080

• Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?

  Journal article

  Andreakos E. et al, (2004), Immunol Rev, 202, 250 - 265

• Emerging approaches for the therapy of autoimmune and chronic inflammatory disease.

  Journal article

  Cope AP. and Feldmann M., (2004), Curr Opin Immunol, 16, 780 - 786

• Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.

  Journal article

  Taylor PC. et al, (2004), Curr Opin Biotechnol, 15, 557 - 563

• Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages.

  Journal article

  Pertyńska-Marczewska M. et al, (2004), Cytokine, 28, 35 - 47

• New approaches to therapeutic immunomodulation for immune-mediated inflammatory disorders.

  Journal article

  Taylor PC. and Feldmann M., (2004), Curr Opin Pharmacol, 4, 368 - 371

• Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.

  Journal article

  Monaco C. et al, (2004), Proc Natl Acad Sci U S A, 101, 5634 - 5639

• P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.

  Journal article

  Sumariwalla PF. et al, (2004), Clin Exp Immunol, 136, 67 - 75

• Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.

  Journal article

  Zhang Y. et al, (2004), J Pharmacol Exp Ther, 309, 348 - 355

• Historical review: Cytokines as therapeutics and targets of therapeutics.

  Journal article

  Vilcek J. and Feldmann M., (2004), Trends Pharmacol Sci, 25, 201 - 209

• TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model.

  Journal article

  Waterston AM. et al, (2004), Br J Cancer, 90, 1279 - 1284

• Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

  Journal article

  Andreakos E. et al, (2004), Blood, 103, 2229 - 2237

• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.

  Journal article

  Sumariwalla PF. et al, (2004), Arthritis Rheum, 50, 985 - 998

• T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases.

  Journal article

  Monaco C. et al, (2004), Curr Drug Targets Inflamm Allergy, 3, 35 - 42

• The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.

  Journal article

  Feldmann M. et al, (2004), Best Pract Res Clin Rheumatol, 18, 59 - 80

• Endotoxin signaling in human macrophages: signaling via an alternate mechanism.

  Journal article

  Sacre SM. et al, (2004), J Endotoxin Res, 10, 445 - 452

• Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?

  Journal article

  Feldmann M. et al, (2004), Novartis Found Symp, 256, 53 - 69

• Advanced glycation end products (AGE) enhance vascular endothelial growth factor (VEGF) production in promonocytic leukaemia THP-1 cells

  Journal article

  Pertńaska-Marczewska M. et al, (2003), Diabetologia Polska, 10, 375 - 380

• Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.

  Journal article

  Foxwell B. et al, (2003), Ann Rheum Dis, 62 Suppl 2, ii90 - ii93

• Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis.

  Journal article

  Afuwape AO. et al, (2003), Gene Ther, 10, 1950 - 1960

• TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

  Journal article

  Feldmann M. and Maini RN., (2003), Nature Medicine, 9, 1245 - 1250

• Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.

  Journal article

  Feldmann M. and Maini RN., (2003), Nat Med, 9, 1245 - 1250

• Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.

  Journal article

  Yoshimura S. et al, (2003), Scand J Immunol, 58, 165 - 172

• Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.

  Journal article

  Scheinin T. et al, (2003), Clin Exp Immunol, 133, 38 - 43

• Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.

  Journal article

  Andreakos E. et al, (2003), Arthritis Rheum, 48, 1901 - 1912

• Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.

  Journal article

  Calder VL. et al, (2003), Scand J Immunol, 57, 261 - 270

• Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response.

  Journal article

  Mauri C. et al, (2003), Arthritis Rheum, 48, 839 - 845

• VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.

  Journal article

  Kiriakidis S. et al, (2003), J Cell Sci, 116, 665 - 674

• Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.

  Journal article

  Andreakos E. et al, (2003), Blood, 101, 983 - 991

• The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.

  Journal article

  Sumariwalla PF. et al, (2003), Arthritis Res Ther, 5, R32 - R39

• Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.

  Journal article

  Foey AD. et al, (2003), Arthritis Res Ther, 5, R317 - R328

• Monoclonal antibodies in immune and inflammatory diseases.

  Journal article

  Andreakos E. et al, (2002), Curr Opin Biotechnol, 13, 615 - 620

• Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

  Journal article

  Feldmann M. et al, (2002), Ann Rheum Dis, 61 Suppl 2, ii13 - ii18

• Cytokines and anti-cytokine biologicals in autoimmunity: present and future.

  Journal article

  Andreakos ET. et al, (2002), Cytokine Growth Factor Rev, 13, 299 - 313

• TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.

  Journal article

  Ciesielski CJ. et al, (2002), Eur J Immunol, 32, 2037 - 2045

• Development of anti-TNF therapy for rheumatoid arthritis.

  Journal article

  Feldmann M., (2002), Nat Rev Immunol, 2, 364 - 371

• T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor.

  Journal article

  Monaco C. et al, (2002), J Leukoc Biol, 71, 659 - 668

• Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.

  Journal article

  Brennan FM. et al, (2002), Arthritis Rheum, 46, 31 - 41

• Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.

  Journal article

  Feldmann M. and Maini RN., (2002), Joint Bone Spine, 69, 12 - 18

• High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.

  Journal article

  Horwood NJ. et al, (2002), Arthritis Res, 4 Suppl 3, S215 - S225

• How does infliximab work in rheumatoid arthritis?

  Journal article

  Maini RN. and Feldmann M., (2002), Arthritis Res, 4 Suppl 2, S22 - S28

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• CELLS THAT SUPPRESS IMMUNITY

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• Lymphokines and interleukins emerge from the primeval soup.

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• Functional expression of HLA-DP genes transfected into mouse fibroblasts.

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• Effects of platelet-derived growth factor and epidermal growth factor on antigen-induced proliferation of human T-cell lines.

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• Mechanism of action of immune response genes.

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• Clonal approaches to immune regulation by lymphocytes.

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• Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction.

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• Inhibition of T cell proliferation by antibodies to synthetic peptides.

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• Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity.

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• Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

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• Antigen-specific and non-specific helper activities derived from supernatants of human influenza virus-specific T-cell lines.

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• Induction of a T-cell mediated suppressor activity by soluble products from antigen-specific helper/inducer human T-cell lines.

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• A human suppressor T cell clone which recognizes an autologous helper T cell clone.

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• An influenza virus matrix protein-specific human T cell line with helper activity for in vitro anti-hemagglutinin antibody production.

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• Specific suppression of antibody responses in vivo. I. Effects of in vitro produced suppressor factor.

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• Genetically restricted and unrestricted antigen specific helper factors

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• Structure of antigen-specific suppressor factors: current views.

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• A comparative study of accessory cells derived from the peritoneum and from solid tissues.

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• Long-term human T-helper lines producing specific helper factor reactive to influenza virus.

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• T-cell hybridomas producing hapten-specific suppressor factors.

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• Antigen-specific helper factor reacts with antibodies to human beta 2 microglobulin.

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• Genetics of human T cell-monocyte interaction in helper cell induction.

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• Nature of macrophage-T cell interaction in secondary helper cell generation in vitro. Genetic restriction of macrophage-T cell interaction, which determines T-B genetic restriction.

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• Induction of human antigen-specific suppressor factors in vitro.

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• Nature of T cell-macrophage interaction in helper cell induction in vitro. III. Responsiveness of T cells differentiating in irradiation or allophenic chimeras depends on the genotype of the host.

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  Erb P. et al, (1980), J Immunol, 124, 2656 - 2664

• Antigen specific T cell factors.

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• Specific T helper and suppressor cells and factors induced in vitro to the hapten NP.

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• Antibody production to antigen-specific factors.

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• Structural characteristics of antigen-specific suppressor factors: definition of 'constant' region and 'variable' region determinants.

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  Kontiainen S. and Feldmann M., (1979), Thymus, 1, 59 - 79

• Selective production of human antigen specific helper factor from normal volunteers: implications for human Ir genes.

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• Serological analysis of antigen-specific helper factors specific for poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] and L Glu60-LAla30-LTyr10 (GAT).

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• Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product?

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• Induction of human antigen-specific and non-specific helper factors in vitro.

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• Nature of T-cell macrophage interaction in helper-cell induction in vitro. II. Two stages of T-helper-cell differentiation analyzed in irradiation and allophenic chimeras.

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  Erb P. et al, (1979), J Exp Med, 149, 686 - 701

• MLC and CMC reactivity and specificity of idiotype-specific lymphoid cells enriched for histocompatibility (H-2) antigens.

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• Human and mouse specific T-cell helper factors assayed in vivo and in vitro: implications for human Ir genes.

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• Suppressor cell induction in vitro. VI. Production of suppressor factors to synthetic polypeptides GAT and (T,G)-A--L from cells of responder and nonresponder mice.

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• Macrophage-lymphocyte interactions in immune induction.

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  Feldmann M. et al, (1979), Int Rev Cytol, 60, 149 - 178

• Comparison of antigen-specific I-region-associated cell interaction factors.

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• Human T-cell responses in vitro: cell interactions and factors.

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• Cellular interactions in antibody production

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  Howie S. and Feldmann M., (1978), Clinics in Rheumatic Diseases, 4, 481 - 498

• Nature of T cell-macrophage interaction in helper cell induction in vitro. I. Evidence for genetic restriction of T cell-macrophage interactions prior to T cell priming.

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  Erb P. et al, (1978), Eur J Immunol, 8, 786 - 792

• T-cell lines producing antigen-specific suppressor factor.

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• Immune response (Ir) genes expressed at macrophage-B lymphocyte interactions.

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• Cellular basis of the humoral immune response in mouse and hamster.

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• Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships.

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• COMPLEMENTATION OF H-2-LINKED IR GENES - USE OF HELPER FACTOR TO ANALYZE RESPONSES TO GLYPHE

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• T cell hybrids with T cell functions.

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• Complexity of cell interactions: analysis using antigens under Ir gene control.

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• Requirement for interactions between two subpopulations of T cells for helper cell induction in vitro.

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• In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.

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  Howie S. and Feldman M., (1977), Eur J Immunol, 7, 417 - 421

• The role of macrophages in the generation of T helper cells. V. Evidence for differential activation of short-lived T1 and long-lived T2 lymphocytes by the macrophage factors GRF and NMF.

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  Erb P. et al, (1977), J Immunol, 119, 206 - 209

• Are the Ir genes expressed by macrophages?

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• Suppressor cell induction in vitro. III. Antigen-specific suppression by supernatants of suppressor cells.

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• T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.

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• In vitro studies on H-2 linked unresponsiveness. 1. Normal helper cells to (T,G)-A-L and GAT in low and non-responder mice.

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• Antigenic phenotypes of T-cell subsets.

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• Current concepts of the antibody response: heterogeneity of lymphoid cells, interactions, and factors.

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• INVITRO STUDIES ON H-2 LINKED UNRESPONSIVENESS .1. NORMAL HELPER CELLS TO (T,G)-A-L AND GAT IN LOW AND NON-RESPONDER MICE

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• Two-gene control of T-helper cell induction.

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• Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.

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• Separation of suppressor and killer T cells by surgace phenotype.

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• Immunological effects of IgT synthesized by theta-positive cell lines.

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• Mechanisms of B-cell tolerance.

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• Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens.

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• Suppressor cell induction in vitro. II. Cellular requirements of suppressor cell induction.

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• Secondary cytotoxic allograft responses in vitro. III. The immunogenicity of allogeneic membrane fragments.

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• Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells.

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• Enrichment of antigen-specific helper and suppressor T cells.

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• Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.

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• The role of macrophages in the generation of T helper cells. III. Influence of macrophage-derived factors in helper cell induction.

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• The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction.

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• T-T interaction in the generation of helper cells in vitro.

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• The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

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• Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. I. Studies with 2,4-dinitrophenyl conjugates in vitro.

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• B Cell heterogeneity - difference in the size of B lymphocytes responding to T dependent and T independent antigens.

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• Role of macrophages in in vitro induction of T-helper cells.

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• Lack of requirement for cell cooperation in the antibody response to DNP conjugated to levan.

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• Role of T-cell immunoglobulin in cell cooperation, T-cell suppression, and antigenic competition.

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• Conditions for inducing T helper cells in vitro.

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• Role of antigen structure in the discrimination between tolerance and immunity by b cells.

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• Tolerance induction to a hapten protein conjugate in vivo: are suppressor T cells involved.

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• Mechanism of antigenic competition. II. Induction by specific T cell products.

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• T cell suppression in vitro. I. Role in regulation of antibody responses.

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• T cell suppression in vitro. II. Nature of specific suppressive factor.

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• Direct triggering of B lymphocytes by insolubilized antigen.

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• The effect of erythrocyte antigen structure on requirement for T cells.

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• Role of C3 in in vitro lymphocyte cooperation.

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• Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes.

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• Cell to cell interactions in the immune response.

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• Thymus-independent IgM and IgG responses in mice to flagellar antigens.

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• Synergy among thymocytes and peripheral lymph node cells in the in vitro generation of lymphocytes cytotoxic to alloantigens.

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• Histocompatibility-linked immune-response genes. What do they do?

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• The mechanism of antigenic competition. I. The macrophage as a site of a reversible block of T-B lymphocyte collaboration.

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• Induction of specific helper cells in vitro.

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• Relative affinity and avidity of the antigen-binding receptors of T and B rosette-forming cells.

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• Cell interactions in the immune response in vitro. VI. Mediation by T cell surface monomeric IgM.

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• Monospecificity of bone marrow-derived lymphocytes.

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• Induction fo B cell tolerance by antigen specific T cell factor.

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• Cellular components of the immune system and their cooperation (T and B cells).

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• Studies on antibody affinity in mice.

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• The role of soluble factors in T-B cell collaboration.

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• Mechanism of antigen binding to receptor antibody in B cell immunity and tolerance in vitro.

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• Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.

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• Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.

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• Humoral and cell mediated responses in vitro of spleen cells from mice with thymic aplasia (nude mice).

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• Induction of immunity and tolerance in vitro by hapten protein conjugates. 3. Hapten inhibition studies of antigen binding to B cells in immunity and tolerance.

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• Mechanisms at the cellular level during induction of high zone tolerance in vitro.

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• Cellular basis of antibody production.

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• Cell-mediated immune response in vitro. 3. The requirement for macrophages in cytotoxic reactions against cell-bound and subcellular alloantigens.

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• Cell interactions in the immune response in vitro. 3. Specific collaboration across a cell impermeable membrane.

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• Cell interactions in the immune response in vitro. I. Metabolic activities of T cells in a collaborative antibody response.

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• Dynamic aspects of antigen binding to B cells in immune induction.

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• Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin.

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• Cell-mediated immune response in vitro. I. A new in vitro system for the generation of cell-mediated cytotoxic activity.

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• Antibody-mediated suppression of the immune response in vitro. IV. The effect of antibody fragments.

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• Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages.

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• Relationship between antigen and antibody-induced suppression of immunity.

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• The detection of autoantibody-forming cells. I. An assay for plaque-forming cells to the basic protein of myelin in guinea-pigs.

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• The detection of autoantibody-forming cells. II. Cells in lymph nodes and central nervous system containing antibody to myelin basic protein.

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  Lennon V. et al, (1972), Int Arch Allergy Appl Immunol, 43, 749 - 758

• The requirement for macrophages in the secondary immune response to antigens of small and large size in vitro.

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  Feldmann M. and Palmer J., (1971), Immunology, 21, 685 - 699

• Antibody-mediated suppression of the immune response in vitro. 3. Low zone tolerance in vitro.

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  Feldmann M. and Diener E., (1971), Immunology, 21, 387 - 404

• The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

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  Feldmann M. and Easten A., (1971), J Exp Med, 134, 103 - 119

• Reversible blocking effect of anti-mouse immunoglobulin serum on the induction of immunity and tolerance in vitro.

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  Feldmann M. and Diener E., (1971), Nat New Biol, 231, 183 - 184

• Induction of immunity and tolerance to the dinitrophenyl determinant in vitro.

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  Feldmann M., (1971), Nat New Biol, 231, 21 - 23

• Induction of low-zone tolerance in vitro.

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  Diener E. and Feldmann M., (1971), Transplant Proc, 3, 663 - 665

• Antibody-mediated suppression of the immune response in vitro. II. A new approach to the phenomenon of immunological tolerance.

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  Diener E. and Feldmann M., (1970), J Exp Med, 132, 31 - 43

• Antibody-mediated suppression of the immune response in vitro. I. Evidence for a central effect.

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  Feldmann M. and Diener E., (1970), J Exp Med, 131, 247 - 274

• Assemblée générale du 13 Mars 1970

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