Sir Marc Feldmann FRS

• Macrophage heterogeneity in the context of rheumatoid arthritis.

  Udalova IA. et al, (2016), Nat Rev Rheumatol, 12, 472 - 485

• Anti-TNF Therapy.

  Udalova I. et al, (2016), Microbiol Spectr, 4

• Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

  Cole JE. et al, (2015), Proc Natl Acad Sci U S A, 112, 13033 - 13038

• Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

  Cribbs A. et al, (2015), Ther Adv Musculoskelet Dis, 7, 206 - 219

• Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss.

  Espirito Santo AI. et al, (2015), Biochem Biophys Res Commun, 464, 1145 - 1150

• Perspectives From Masters in Rheumatology and Autoimmunity: Can We Get Closer to a Cure for Rheumatoid Arthritis?

  Feldmann M. and Maini RN., (2015), Arthritis Rheumatol, 67, 2283 - 2291

• IRF5 controls both acute and chronic inflammation.

  Weiss M. et al, (2015), Proc Natl Acad Sci U S A, 112, 11001 - 11006

• IRF5 controls both acute and chronic inflammation

  Weiss M. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 11001 - 11006

• Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.

  Chan JK. et al, (2015), EMBO Mol Med, 7, 547 - 561

• Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

  Terrando N. et al, (2015), Mol Med, 20, 667 - 675

• Preclinical target validation using patient-derived cells.

  Edwards AM. et al, (2015), Nat Rev Drug Discov, 14, 149 - 150

• Anti-TNF therapy: past, present and future.

  Monaco C. et al, (2015), Int Immunol, 27, 55 - 62

• Design and optimisation of bioactive cyclic peptides: generation of a down-regulator of TNF secretion.

  New R. et al, (2014), Molecules, 19, 21529 - 21540

• Discovery and Development of Anti-TNF Therapy: Pillar of a Therapeutic Revolution. Pillar of a Therapeutic Revolution.

  Feldmann M., (2014), Molecular Biology of B Cells: Second Edition, 541 - 547

• Natural killer (NK) cells and gamma delta T-cells differentially modulate Th17-driven disease in ankylosing spondylitis

  Wythe SE. et al, (2014), IMMUNOLOGY, 143, 162 - 162

• Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

  McCann FE. et al, (2014), Arthritis Rheumatol, 66, 2728 - 2738

• Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

  Nielsen N. et al, (2014), Immunology, 142, 581 - 593

• Reply: To PMID 23784528.

  Schmidt EM. et al, (2014), Arthritis Rheumatol, 66, 1962 - 1963

• TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

  Ruspi G. et al, (2014), Cell Signal, 26, 683 - 690

• OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

  Gwyer Findlay E. et al, (2014), Proc Natl Acad Sci U S A, 111, 2289 - 2294

• Anti-tnf therapy: 20 years from our first therapeutic adventure

  Nanchahal J. et al, (2014), Cytokine Frontiers: Regulation of Immune Responses in Health and Disease, 215 - 244

• A conversation with Marc Feldmann. Interviewed by Ushma S. Neill.

  Feldmann M., (2014), J Clin Invest, 124, 1 - 2

• Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.

  Schmidt EM. et al, (2013), Arthritis Rheum, 65, 2262 - 2273

• Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

  Verjee LS. et al, (2013), Proc Natl Acad Sci U S A, 110, E928 - E937

• RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.

  Gasparini C. et al, (2013), Cytokine, 61, 736 - 740

• TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes.

  Brenner C. et al, (2012), Scand J Immunol, 76, 359 - 370

• Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA.

  Larsen H. et al, (2012), Arthritis Res Ther, 14

• Alarmins: awaiting a clinical response.

  Chan JK. et al, (2012), J Clin Invest, 122, 2711 - 2719

• Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis.

  Raatz Y. et al, (2012), Arthritis Res Ther, 14

• Effective targeting of the tumor microenvironment for cancer therapy.

  Jiang P. et al, (2012), Anticancer Res, 32, 1203 - 1212

• NF-κB as a target for modulating inflammatory responses.

  Gasparini C. and Feldmann M., (2012), Curr Pharm Des, 18, 5735 - 5745

• The TNF/TNF-R family: A gold mine for clinical therapeutic targets?

  Feldmann M., (2011), Advances in Experimental Medicine and Biology, 691, ix - x

• Resolving postoperative neuroinflammation and cognitive decline.

  Terrando N. et al, (2011), Ann Neurol, 70, 986 - 995

• Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

  Beavis PA. et al, (2011), Proc Natl Acad Sci U S A, 108, 16717 - 16722

• Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.

  Andersson AK. et al, (2011), Arthritis Rheum, 63, 2617 - 2629

• IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

  McNamee KE. et al, (2011), Pain, 152, 1838 - 1845

• IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

  Krausgruber T. et al, (2011), Nat Immunol, 12, 231 - 238

• Unexpected protective role for Toll-like receptor 3 in the arterial wall.

  Cole JE. et al, (2011), Proc Natl Acad Sci U S A, 108, 2372 - 2377

• TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells.

  Glass GE. et al, (2011), Proc Natl Acad Sci U S A, 108, 1585 - 1590

• Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade.

  Gompels LL. et al, (2011), Arthritis Res Ther, 13

• Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.

  Turner JJ. et al, (2010), Clin Exp Immunol, 162, 487 - 493

• Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.

  Terrando N. et al, (2010), Proc Natl Acad Sci U S A, 107, 20518 - 20522

• Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis.

  Malik NM. et al, (2010), Rheumatology (Oxford), 49, 1828 - 1839

• IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.

  Smallie T. et al, (2010), J Exp Med, 207, 2081 - 2088

• Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

  Page TH. et al, (2010), J Immunol, 185, 3694 - 3701

• Role of interleukin-1beta in postoperative cognitive dysfunction.

  Cibelli M. et al, (2010), Ann Neurol, 68, 360 - 368

• The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity.

  Weng L. et al, (2010), Ann Rheum Dis, 69, 1519 - 1526

• SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

  Drexler SK. et al, (2010), Arthritis Rheum, 62, 2249 - 2261

• Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

  Feldmann M. and Maini RN., (2010), J Immunol, 185, 791 - 794

• Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.

  Drexler SK. et al, (2010), Scand J Immunol, 71, 393 - 402

• Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.

  McNamee KE. et al, (2010), Pain, 149, 386 - 392

• Directed issue: novel concepts in inflammation.

  Gilroy DW. et al, (2010), Int J Biochem Cell Biol, 42, 480 - 481

• Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis.

  Dobson R. et al, (2010), J Neuroimmunol, 220, 99 - 103

• What have we learnt from targeted anti-TNF therapy?

  Feldmann M. et al, (2010), Ann Rheum Dis, 69 Suppl 1, i97 - i99

• The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.

  Terrando N. et al, (2010), Crit Care, 14

• Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.

  Wegner N. et al, (2010), Immunol Rev, 233, 34 - 54

• Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

  McCann FE. et al, (2010), Arthritis Res Ther, 12

• Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis.

  Monaco C. et al, (2009), Circulation, 120, 2462 - 2469

• Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

  Hillyer P. et al, (2009), Rheumatology (Oxford), 48, 1581 - 1589

• TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

  Kuai J. et al, (2009), Rheumatology (Oxford), 48, 1352 - 1358

• Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.

  Taylor PC. and Feldmann M., (2009), Nat Rev Rheumatol, 5, 578 - 582

• A view from a European medical academic who spends time in the US.

  Feldmann M., (2009), J Clin Invest, 119, 2861 - 2862

• RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

  Gasparini C. et al, (2009), Eur J Immunol, 39, 2215 - 2223

• Translating molecular insights in autoimmunity into effective therapy.

  Feldmann M., (2009), Annu Rev Immunol, 27, 1 - 27

• Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

  Sumariwalla PF. et al, (2009), Rheumatology (Oxford), 48, 32 - 38

• In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.

  Brennan F. and Feldmann M., (2009), Arthritis Res Ther, 11

• Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

  Sacre SM. et al, (2008), J Immunol, 181, 8002 - 8009

• Many cytokines are very useful therapeutic targets in disease.

  Feldmann M., (2008), J Clin Invest, 118, 3533 - 3536

• Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.

  Inglis JJ. et al, (2008), Arthritis Rheum, 58, 3110 - 3119

• Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

  Raichel L. et al, (2008), Eur J Immunol, 38, 2905 - 2915

• Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis.

  Sumariwalla PF. et al, (2008), Arthritis Rheum, 58, 3071 - 3080

• Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.

  Andersson AK. et al, (2008), Scand J Immunol, 68, 103 - 111

• Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.

  Feldmann M. and Maini SR., (2008), Immunol Rev, 223, 7 - 19

• Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

  Williams LM. et al, (2008), Mol Immunol, 45, 2446 - 2454

• CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.

  Simelyte E. et al, (2008), Arthritis Rheum, 58, 1038 - 1043

• Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.

  Brennan FM. et al, (2008), Arthritis Res Ther, 10

• Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

  Jin P. et al, (2008), Arthritis Res Ther, 10

• Targeting intracellular signaling: a novel approach to vaccination.

  Wales J. et al, (2007), Expert Rev Vaccines, 6, 971 - 980

• Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.

  Wales J. et al, (2007), Biochem Soc Trans, 35, 1501 - 1503

• Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.

  Inglis JJ. et al, (2007), Arthritis Rheum, 56, 4015 - 4023

• Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

  Lundberg AM. et al, (2007), Blood, 110, 3245 - 3252

• Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

  Sacre SM. et al, (2007), Ann Rheum Dis, 66 Suppl 3, iii81 - iii86

• The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.

  Inglis JJ. et al, (2007), Rheumatology (Oxford), 46, 1428 - 1432

• Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.

  Williams RO. et al, (2007), Curr Opin Pharmacol, 7, 412 - 417

• Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.

  Sheryanna A. et al, (2007), J Am Soc Nephrol, 18, 1167 - 1179

• Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

  Bondeson J. et al, (2007), J Rheumatol, 34, 523 - 533

• A new JCI conflict-of-interest policy.

  Neill US. et al, (2007), J Clin Invest, 117, 506 - 508

• Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.

  Sacre SM. et al, (2007), J Immunol, 178, 2148 - 2154

• The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.

  Sacre SM. et al, (2007), Am J Pathol, 170, 518 - 525

• The pitfalls in the development of biologic therapy.

  Maini RN. and Feldmann M., (2007), Nat Clin Pract Rheumatol, 3

• Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.

  Edwards CJ. et al, (2007), Mol Med, 13, 40 - 58

• Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.

  Tyndall A. et al, (2007), Arthritis Res Ther, 9

• Crystal-ball gazing--the future of immunological research viewed from the cutting edge.

  Brent L. et al, (2007), Clin Exp Immunol, 147, 1 - 10

• Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.

  Inglis JJ. et al, (2007), Arthritis Res Ther, 9

• Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

  Amos N. et al, (2006), Rheumatology (Oxford), 45, 1201 - 1209

• Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.

  Andreakos E. et al, (2006), Proc Natl Acad Sci U S A, 103, 14459 - 14464

• Cytokines as therapeutics and targets of therapeutics

  Vilček J. and Feldmann M., (2006), Rheumatologia, 20, 65 - 74

• Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.

  Feldmann M. and Pusey CD., (2006), J Am Soc Nephrol, 17, 1243 - 1252

• Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.

  Grosjean J. et al, (2006), Biochem Biophys Res Commun, 340, 984 - 994

• The importance of T cell interactions with macrophages in rheumatoid cytokine production.

  Brennan FM. et al, (2006), Curr Top Microbiol Immunol, 305, 177 - 194

• The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.

  Andreakos E. et al, (2005), Front Biosci, 10, 2478 - 2488

• Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.

  Waterston AM. et al, (2005), Cancer Immunol Immunother, 54, 848 - 857

• Molecular therapeutic targets in rheumatoid arthritis.

  Sacre SM. et al, (2005), Expert Rev Mol Med, 7, 1 - 20

• Design of effective immunotherapy for human autoimmunity.

  Feldmann M. and Steinman L., (2005), Nature, 435, 612 - 619

• Cannabinoids in Models of Chronic Inflammatory Conditions

  Mechoulam R. et al, (2005), Phytochemistry Reviews, 4, 11 - 18

• Anti-TNF therapy: where have we got to in 2005?

  Feldmann M. et al, (2005), J Autoimmun, 25 Suppl, 26 - 28

• Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.

  Taylor PC. et al, (2004), Curr Opin Biotechnol, 15, 557 - 563

• Rheumatoid arthritis: pathogenic mechanisms and therapeutic targets

  Taylor PC. and Feldmann M., (2004), Drug Discovery Today: Disease Mechanisms, 1, 289 - 295

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

  Burstein S. and Zurier RB., (2004), Arthritis Rheum, 50, 4078 - 4079

• Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al - Reply

  Sumariwalla PF. et al, (2004), ARTHRITIS AND RHEUMATISM, 50, 4079 - 4080

• Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?

  Andreakos E. et al, (2004), Immunol Rev, 202, 250 - 265

• Emerging approaches for the therapy of autoimmune and chronic inflammatory disease.

  Cope AP. and Feldmann M., (2004), Curr Opin Immunol, 16, 780 - 786

• A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.

  Campbell J. et al, (2004), J Immunol, 173, 6928 - 6937

• Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages.

  Pertyńska-Marczewska M. et al, (2004), Cytokine, 28, 35 - 47

• New approaches to therapeutic immunomodulation for immune-mediated inflammatory disorders.

  Taylor PC. and Feldmann M., (2004), Curr Opin Pharmacol, 4, 368 - 371

• Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.

  Monaco C. et al, (2004), Proc Natl Acad Sci U S A, 101, 5634 - 5639

• P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.

  Sumariwalla PF. et al, (2004), Clin Exp Immunol, 136, 67 - 75

• Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.

  Zhang Y. et al, (2004), J Pharmacol Exp Ther, 309, 348 - 355

• Historical review: Cytokines as therapeutics and targets of therapeutics.

  Vilcek J. and Feldmann M., (2004), Trends Pharmacol Sci, 25, 201 - 209

• TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model.

  Waterston AM. et al, (2004), Br J Cancer, 90, 1279 - 1284

• Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

  Andreakos E. et al, (2004), Blood, 103, 2229 - 2237

• T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases.

  Monaco C. et al, (2004), Curr Drug Targets Inflamm Allergy, 3, 35 - 42

• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.

  Sumariwalla PF. et al, (2004), Arthritis Rheum, 50, 985 - 998

• The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.

  Feldmann M. et al, (2004), Best Pract Res Clin Rheumatol, 18, 59 - 80

• Endotoxin signaling in human macrophages: signaling via an alternate mechanism.

  Sacre SM. et al, (2004), J Endotoxin Res, 10, 445 - 452

• Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?

  Feldmann M. et al, (2004), Novartis Found Symp, 256, 53 - 69

• Advanced glycation end products (AGE) enhance vascular endothelial growth factor (VEGF) production in promonocytic leukaemia THP-1 cells

  Pertńaska-Marczewska M. et al, (2003), Diabetologia Polska, 10, 375 - 380

• Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.

  Foxwell B. et al, (2003), Ann Rheum Dis, 62 Suppl 2, ii90 - ii93

• Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis.

  Afuwape AO. et al, (2003), Gene Ther, 10, 1950 - 1960

• TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

  Feldmann M. and Maini RN., (2003), Nature Medicine, 9, 1245 - 1250

• Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.

  Feldmann M. and Maini RN., (2003), Nat Med, 9, 1245 - 1250

• Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.

  Yoshimura S. et al, (2003), Scand J Immunol, 58, 165 - 172

• Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.

  Scheinin T. et al, (2003), Clin Exp Immunol, 133, 38 - 43

• Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.

  Andreakos E. et al, (2003), Arthritis Rheum, 48, 1901 - 1912

• Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response.

  Mauri C. et al, (2003), Arthritis Rheum, 48, 839 - 845

• Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.

  Calder VL. et al, (2003), Scand J Immunol, 57, 261 - 270

• VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.

  Kiriakidis S. et al, (2003), J Cell Sci, 116, 665 - 674

• Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.

  Andreakos E. et al, (2003), Blood, 101, 983 - 991

• The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.

  Sumariwalla PF. et al, (2003), Arthritis Res Ther, 5, R32 - R39

• Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.

  Foey AD. et al, (2003), Arthritis Res Ther, 5, R317 - R328

• Monoclonal antibodies in immune and inflammatory diseases.

  Andreakos E. et al, (2002), Curr Opin Biotechnol, 13, 615 - 620

• Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

  Feldmann M. et al, (2002), Ann Rheum Dis, 61 Suppl 2, ii13 - ii18

• Cytokines and anti-cytokine biologicals in autoimmunity: present and future.

  Andreakos ET. et al, (2002), Cytokine Growth Factor Rev, 13, 299 - 313

• TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.

  Ciesielski CJ. et al, (2002), Eur J Immunol, 32, 2037 - 2045

• Development of anti-TNF therapy for rheumatoid arthritis.

  Feldmann M., (2002), Nat Rev Immunol, 2, 364 - 371

• T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor.

  Monaco C. et al, (2002), J Leukoc Biol, 71, 659 - 668

• How does infliximab work in rheumatoid arthritis?

  Maini RN. and Feldmann M., (2002), Arthritis Res, 4 Suppl 2, S22 - S28

• High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.

  Horwood NJ. et al, (2002), Arthritis Res, 4 Suppl 3, S215 - S225

• Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.

  Brennan FM. et al, (2002), Arthritis Rheum, 46, 31 - 41

• Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.

  Feldmann M. and Maini RN., (2002), Joint Bone Spine, 69, 12 - 18

• Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.

  Foey A. et al, (2002), Arthritis Res, 4, 64 - 70

• CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.

  Foey AD. et al, (2001), Cytokine, 16, 131 - 142

• NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts

  Smith C. et al, (2001), Journal of Immunology, 167, 5895 - 5903

• NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.

  Smith C. et al, (2001), J Immunol, 167, 5895 - 5903

• High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.

  Foxwell BM. et al, (2001), Ann Rheum Dis, 60 Suppl 3, iii13 - iii17

• Immunotherapy - Editorial overview

  Feldmann M., (2001), CURRENT OPINION IN IMMUNOLOGY, 13, 595 - 596

• Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.

  Ballara S. et al, (2001), Arthritis Rheum, 44, 2055 - 2064

• Pathogenesis of arthritis: recent research progress.

  Feldmann M., (2001), Nat Immunol, 2, 771 - 773

• Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.

  Conron M. et al, (2001), Am J Respir Cell Mol Biol, 25, 141 - 149

• Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.

  Yoshimura S. et al, (2001), Eur J Immunol, 31, 1883 - 1893

• Gene therapy for rheumatoid arthritis?

  Feldmann M., (2001), J Clin Invest, 107

• Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver.

  Quattrocchi E. et al, (2001), J Immunol, 166, 5970 - 5978

• Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.

  Yoshimura S. et al, (2001), Int Immunol, 13, 675 - 683

• Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.

  Malfait AM. et al, (2001), Arthritis Rheum, 44, 1215 - 1224

• Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities.

  Feldmann M. et al, (2001), Transplant Proc, 33, 2085 - 2086

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  Fischer A. et al, (1981), Nature, 294, 166 - 168

• T-cell hybridomas producing hapten-specific suppressor factors.

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• Antigen-specific helper factor reacts with antibodies to human beta 2 microglobulin.

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• Genetics of human T cell-monocyte interaction in helper cell induction.

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• Nature of macrophage-T cell interaction in secondary helper cell generation in vitro. Genetic restriction of macrophage-T cell interaction, which determines T-B genetic restriction.

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• Induction of human antigen-specific suppressor factors in vitro.

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• Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.

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• Nature of T cell-macrophage interaction in helper cell induction in vitro. III. Responsiveness of T cells differentiating in irradiation or allophenic chimeras depends on the genotype of the host.

  Erb P. et al, (1980), J Immunol, 124, 2656 - 2664

• Antigen specific T cell factors.

  Feldmann M. and Kontiainen S., (1980), Mol Cell Biochem, 30, 177 - 193

• Specific T helper and suppressor cells and factors induced in vitro to the hapten NP.

  Kontiainen S. and Feldmann M., (1980), Ann Immunol (Paris), 131C, 239 - 255

• Antibody production to antigen-specific factors.

  Feldmann M. et al, (1980), Contemp Top Immunobiol, 11, 275 - 289

• Structural characteristics of antigen-specific suppressor factors: definition of 'constant' region and 'variable' region determinants.

  Kontiainen S. and Feldmann M., (1979), Thymus, 1, 59 - 79

• Selective production of human antigen specific helper factor from normal volunteers: implications for human Ir genes.

  Zvaifler NJ. et al, (1979), Clin Exp Immunol, 37, 328 - 338

• Induction of antibody responses in vivo by antigen specific helper factor.

  Woody JN. et al, (1979), Immunobiology, 156, 13 - 24

• Serological analysis of antigen-specific helper factors specific for poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] and L Glu60-LAla30-LTyr10 (GAT).

  Howie S. et al, (1979), Eur J Immunol, 9, 501 - 506

• Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product?

  Erb P. et al, (1979), J Immunol, 122, 1916 - 1919

• Induction of human antigen-specific and non-specific helper factors in vitro.

  Kantor F. and Feldmann M., (1979), Clin Exp Immunol, 36, 71 - 77

• Nature of T-cell macrophage interaction in helper-cell induction in vitro. II. Two stages of T-helper-cell differentiation analyzed in irradiation and allophenic chimeras.

  Erb P. et al, (1979), J Exp Med, 149, 686 - 701

• MLC and CMC reactivity and specificity of idiotype-specific lymphoid cells enriched for histocompatibility (H-2) antigens.

  Folks TM. et al, (1979), Transplant Proc, 11, 683 - 689

• Human and mouse specific T-cell helper factors assayed in vivo and in vitro: implications for human Ir genes.

  Woody JN. et al, (1979), Transplant Proc, 11, 382 - 388

• Suppressor cell induction in vitro. VI. Production of suppressor factors to synthetic polypeptides GAT and (T,G)-A--L from cells of responder and nonresponder mice.

  Kontianen S. et al, (1979), J Immunol, 122, 253 - 259

• Macrophage-lymphocyte interactions in immune induction.

  Feldmann M. et al, (1979), Int Rev Cytol, 60, 149 - 178

• Human T-cell responses in vitro: cell interactions and factors.

  Rees A. et al, (1979), Ann N Y Acad Sci, 332, 503 - 515

• Comparison of antigen-specific I-region-associated cell interaction factors.

  Feldmann M. et al, (1979), Ann N Y Acad Sci, 332, 591 - 604

• Cellular interactions in antibody production

  Howie S. and Feldmann M., (1978), Clinics in Rheumatic Diseases, 4, 481 - 498

• Nature of T cell-macrophage interaction in helper cell induction in vitro. I. Evidence for genetic restriction of T cell-macrophage interactions prior to T cell priming.

  Erb P. et al, (1978), Eur J Immunol, 8, 786 - 792

• T-cell lines producing antigen-specific suppressor factor.

  Kontiainen S. et al, (1978), Nature, 274, 477 - 480

• Immune response (Ir) genes expressed at macrophage-B lymphocyte interactions.

  Howie S. and Feldmann M., (1978), Nature, 273, 664 - 666

• Cellular basis of the humoral immune response in mouse and hamster.

  Erb P. et al, (1978), Fed Proc, 37, 2032 - 2034

• T cell hybrids with T cell functions.

  Simpson E. et al, (1978), Curr Top Microbiol Immunol, 81, 195 - 202

• Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships.

  Kontiainen S. and Feldmann M., (1978), J Exp Med, 147, 110 - 122

• Complexity of cell interactions: analysis using antigens under Ir gene control.

  Baltz M. et al, (1978), Adv Exp Med Biol, 98, 325 - 338

• COMPLEMENTATION OF H-2-LINKED IR GENES - USE OF HELPER FACTOR TO ANALYZE RESPONSES TO GLYPHE

  BALTZ M. et al, (1978), IMMUNOGENETICS, 6, 471 - 481

• Requirement for interactions between two subpopulations of T cells for helper cell induction in vitro.

  Feldmann M. and Erb P., (1977), Z Immunitatsforsch Immunobiol, 153, 217 - 225

• The role of macrophages in the generation of T helper cells. V. Evidence for differential activation of short-lived T1 and long-lived T2 lymphocytes by the macrophage factors GRF and NMF.

  Erb P. et al, (1977), J Immunol, 119, 206 - 209

• In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.

  Howie S. and Feldman M., (1977), Eur J Immunol, 7, 417 - 421

• Are the Ir genes expressed by macrophages?

  Feldmann M., (1977), Nature, 267

• Suppressor cell induction in vitro. III. Antigen-specific suppression by supernatants of suppressor cells.

  Kontianinen S. and Feldmann M., (1977), Eur J Immunol, 7, 310 - 314

• Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells.

  Woody JN. et al, (1977), J Immunol, 118, 1739 - 1743

• T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.

  Feldmann M. et al, (1977), J Exp Med, 145, 793 - 801

• In vitro studies on H-2 linked unresponsiveness. 1. Normal helper cells to (T,G)-A-L and GAT in low and non-responder mice.

  Howie S. et al, (1977), Immunology, 32, 291 - 299

• Antigenic phenotypes of T-cell subsets.

  Beverley PC. et al, (1977), Transplant Proc, 9, 703 - 704

• INVITRO STUDIES ON H-2 LINKED UNRESPONSIVENESS .1. NORMAL HELPER CELLS TO (T,G)-A-L AND GAT IN LOW AND NON-RESPONDER MICE

  HOWIE S. et al, (1977), IMMUNOLOGY, 32, 291 - 299

• Current concepts of the antibody response: heterogeneity of lymphoid cells, interactions, and factors.

  Feldmann M. et al, (1977), Cold Spring Harb Symp Quant Biol, 41 Pt 1, 113 - 118

• Two-gene control of T-helper cell induction.

  Erb P. et al, (1976), Nature, 263, 601 - 604

• Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.

  Desaymard C. et al, (1976), Eur J Immunol, 6, 646 - 650

• Separation of suppressor and killer T cells by surgace phenotype.

  Beverley PC. et al, (1976), Nature, 262, 495 - 497

• Immunological effects of IgT synthesized by theta-positive cell lines.

  Feldmann M. et al, (1976), Eur J Immunol, 5, 429 - 431

• Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens.

  Erb P. et al, (1976), Eur J Immunol, 6, 365 - 372

• Mechanisms of B-cell tolerance.

  Klaus GG. et al, (1976), Br Med Bull, 32, 141 - 146

• Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells.

  Kontiainen S. and Feldmann M., (1976), Eur J Immunol, 6, 296 - 301

• Suppressor cell induction in vitro. II. Cellular requirements of suppressor cell induction.

  Feldmann M. and Kontiainen S., (1976), Eur J Immunol, 6, 302 - 305

• Secondary cytotoxic allograft responses in vitro. III. The immunogenicity of allogeneic membrane fragments.

  Wagner H. et al, (1976), Transplantation, 21, 282 - 288

• Enrichment of antigen-specific helper and suppressor T cells.

  Maoz A. et al, (1976), Nature, 260, 324 - 327

• Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.

  Feldmann M. et al, (1975), Nature, 258, 614 - 616

• The role of macrophages in the generation of T helper cells. III. Influence of macrophage-derived factors in helper cell induction.

  Erb P. and Feldmann M., (1975), Eur J Immunol, 5, 759 - 766

• The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction.

  Erb P. and Feldmann M., (1975), Cell Immunol, 19, 356 - 367

• T-T interaction in the generation of helper cells in vitro.

  Feldmann M. et al, (1975), Nature, 256, 741 - 743

• The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

  Erb P. and Feldmann M., (1975), J Exp Med, 142, 460 - 472

• Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. I. Studies with 2,4-dinitrophenyl conjugates in vitro.

  Desaymard C. and Feldmann M., (1975), Eur J Immunol, 5, 537 - 541

• B Cell heterogeneity - difference in the size of B lymphocytes responding to T dependent and T independent antigens.

  Gorczynski RM. and Feldmann M., (1975), Cell Immunol, 18, 88 - 97

• Role of macrophages in in vitro induction of T-helper cells.

  Erb P. and Feldmann M., (1975), Nature, 254, 352 - 354

• Lack of requirement for cell cooperation in the antibody response to DNP conjugated to levan.

  Desaymard C. and Feldmann M., (1975), Cell Immunol, 16, 106 - 114

• Role of T-cell immunoglobulin in cell cooperation, T-cell suppression, and antigenic competition.

  Feldmann M. et al, (1975), Ann N Y Acad Sci, 249, 424 - 437

• Role of antigen structure in the discrimination between tolerance and immunity by b cells.

  Feldmann M. et al, (1975), Transplant Rev, 23, 78 - 97

• Conditions for inducing T helper cells in vitro.

  Kontiainen S. and Feldmann M., (1975), Scand J Immunol, 4, 121 - 128

• Tolerance induction to a hapten protein conjugate in vivo: are suppressor T cells involved.

  Huchet R. and Feldmann M., (1974), Eur J Immunol, 4, 768 - 771

• Mechanism of antigenic competition. II. Induction by specific T cell products.

  Feldmann M. and Schrader JW., (1974), Cell Immunol, 14, 255 - 269

• T cell suppression in vitro. II. Nature of specific suppressive factor.

  Feldmann M., (1974), Eur J Immunol, 4, 667 - 674

• T cell suppression in vitro. I. Role in regulation of antibody responses.

  Feldmann M., (1974), Eur J Immunol, 4, 660 - 666

• Direct triggering of B lymphocytes by insolubilized antigen.

  Feldmann M. et al, (1974), Eur J Immunol, 4, 591 - 597

• The effect of erythrocyte antigen structure on requirement for T cells.

  Byrd W. et al, (1974), Immunology, 27, 331 - 337

• Role of C3 in in vitro lymphocyte cooperation.

  Feldmann M. and Pepys MB., (1974), Nature, 249, 159 - 161

• Thymus-independent IgM and IgG responses in mice to flagellar antigens.

  Huchet R. and Feldmann M., (1974), Int Arch Allergy Appl Immunol, 46, 600 - 611

• Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes.

  Cone RE. et al, (1974), Immunology, 26, 49 - 60

• Cell to cell interactions in the immune response.

  Feldmann M., (1974), Ser Haematol, 7, 593 - 609

• Synergy among thymocytes and peripheral lymph node cells in the in vitro generation of lymphocytes cytotoxic to alloantigens.

  Tigelaar RE. and Feldmann M., (1973), Transplant Proc, 5, 1711 - 1715

• Histocompatibility-linked immune-response genes. What do they do?

  Feldmann M., (1973), Transplant Proc, 5, 1803 - 1809

• The mechanism of antigenic competition. I. The macrophage as a site of a reversible block of T-B lymphocyte collaboration.

  Schrader JW. and Feldmann M., (1973), Eur J Immunol, 3, 711 - 717

• Induction of specific helper cells in vitro.

  Kontianen S. and Feldmann M., (1973), Nat New Biol, 245, 285 - 286

• Relative affinity and avidity of the antigen-binding receptors of T and B rosette-forming cells.

  Wilson JD. and Feldmann M., (1973), Nat New Biol, 245, 177 - 180

• Cell interactions in the immune response in vitro. VI. Mediation by T cell surface monomeric IgM.

  Feldmann M. et al, (1973), Cell Immunol, 9, 1 - 11

• Monospecificity of bone marrow-derived lymphocytes.

  Raff MC. et al, (1973), J Exp Med, 137, 1024 - 1030

• Induction fo B cell tolerance by antigen specific T cell factor.

  Feldman M., (1973), Nat New Biol, 242, 82 - 84

• Role of T-cell antigen-specific factor in T-B cooperation.

  Feldmann M., (1973), Transplant Proc, 5, 111 - 114

• Cellular components of the immune system and their cooperation (T and B cells).

  Feldmann M., (1973), Transplant Proc, 5, 43 - 48

• The role of soluble factors in T-B cell collaboration.

  Basten A. and Feldmann M., (1973), Adv Exp Med Biol, 29, 171 - 178

• Studies on antibody affinity in mice.

  Huchet R. and Feldmann M., (1973), Eur J Immunol, 3, 49 - 55

• Mechanism of antigen binding to receptor antibody in B cell immunity and tolerance in vitro.

  Feldmann M., (1973), Adv Exp Med Biol, 29, 363 - 368

• Humoral and cell mediated responses in vitro of spleen cells from mice with thymic aplasia (nude mice).

  Feldmann M. et al, (1972), Aust J Exp Biol Med Sci, 50, 651 - 660

• Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.

  Feldmann M., (1972), J Exp Med, 136, 737 - 760

• Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.

  Feldmann M. and Basten A., (1972), J Exp Med, 136, 722 - 736

• Mechanisms at the cellular level during induction of high zone tolerance in vitro.

  Diener E. and Feldmann M., (1972), Cell Immunol, 5, 130 - 136

• Induction of immunity and tolerance in vitro by hapten protein conjugates. 3. Hapten inhibition studies of antigen binding to B cells in immunity and tolerance.

  Feldmann M., (1972), J Exp Med, 136, 532 - 545

• Cellular basis of antibody production.

  Feldmann M. and Nossal GJ., (1972), Q Rev Biol, 47, 269 - 302

• Cell-mediated immune response in vitro. 3. The requirement for macrophages in cytotoxic reactions against cell-bound and subcellular alloantigens.

  Wagner H. et al, (1972), J Exp Med, 136, 331 - 343

• Cell interactions in the immune response in vitro. 3. Specific collaboration across a cell impermeable membrane.

  Feldmann M. and Basten A., (1972), J Exp Med, 136, 49 - 67

• Cell interactions in the immune response in vitro. I. Metabolic activities of T cells in a collaborative antibody response.

  Feldmann M. and Basten A., (1972), Eur J Immunol, 2, 213 - 224

• Specific collaboration between T and B lymphocytes across a cell impermeable membrane in vitro.

  Feldmann M. and Basten A., (1972), Nat New Biol, 237, 13 - 15

• Dynamic aspects of antigen binding to B cells in immune induction.

  Wilson JD. and Feldmann M., (1972), Nat New Biol, 237, 3 - 5

• Cell-mediated immune response in vitro. II. The role of thymus and thymus-derived lymphocytes.

  Wagner H. et al, (1972), Cell Immunol, 4, 39 - 50

• Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration.

  Feldmann M., (1972), J Exp Med, 135, 1049 - 1058

• Induction of immunity and tolerance in vitro by hapten protein conjugates. I. The relationship between the degree of hapten conjugation and the immunogenicity of dinitrophenylated polymerized flagellin.

  Feldmann M., (1972), J Exp Med, 135, 735 - 753

• Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin.

  Feldmann M., (1972), Eur J Immunol, 2, 130 - 137

• Cell-mediated immune response in vitro. I. A new in vitro system for the generation of cell-mediated cytotoxic activity.

  Wagner H. and Feldmann M., (1972), Cell Immunol, 3, 405 - 420

• Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages.

  Feldmann M. and Nossal GJ., (1972), Transplant Rev, 13, 3 - 34

• The detection of autoantibody-forming cells. I. An assay for plaque-forming cells to the basic protein of myelin in guinea-pigs.

  Lennon V. and Feldmann M., (1972), Int Arch Allergy Appl Immunol, 42, 627 - 640

• The detection of autoantibody-forming cells. II. Cells in lymph nodes and central nervous system containing antibody to myelin basic protein.

  Lennon V. et al, (1972), Int Arch Allergy Appl Immunol, 43, 749 - 758

• Relationship between antigen and antibody-induced suppression of immunity.

  Diener E. and Feldmann M., (1972), Transplant Rev, 8, 76 - 103

• Antibody-mediated suppression of the immune response in vitro. IV. The effect of antibody fragments.

  Feldmann M. and Diener E., (1972), J Immunol, 108, 93 - 101

• The requirement for macrophages in the secondary immune response to antigens of small and large size in vitro.

  Feldmann M. and Palmer J., (1971), Immunology, 21, 685 - 699

• Antibody-mediated suppression of the immune response in vitro. 3. Low zone tolerance in vitro.

  Feldmann M. and Diener E., (1971), Immunology, 21, 387 - 404

• The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

  Feldmann M. and Easten A., (1971), J Exp Med, 134, 103 - 119

• Reversible blocking effect of anti-mouse immunoglobulin serum on the induction of immunity and tolerance in vitro.

  Feldmann M. and Diener E., (1971), Nat New Biol, 231, 183 - 184

• Induction of immunity and tolerance to the dinitrophenyl determinant in vitro.

  Feldmann M., (1971), Nat New Biol, 231, 21 - 23

• Induction of low-zone tolerance in vitro.

  Diener E. and Feldmann M., (1971), Transplant Proc, 3, 663 - 665

• Antibody-mediated suppression of the immune response in vitro. II. A new approach to the phenomenon of immunological tolerance.

  Diener E. and Feldmann M., (1970), J Exp Med, 132, 31 - 43

• Antibody-mediated suppression of the immune response in vitro. I. Evidence for a central effect.

  Feldmann M. and Diener E., (1970), J Exp Med, 131, 247 - 274

• Assemblée générale du 13 Mars 1970

  (1970), Bulletin de la Société Botanique de France, 117, 177 - 177

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