Claire Pearson

Senior Gnotobiology Scientist

When not managing the lab my research focuses on how the intestinal immune system interacts with the bacteria residing within us, and how changes in the balance between this microbiome and the immune system can affect inflammatory disease. In my role as Senior Gnotobiology Scientist I also help to coordinate and run experiments for others interested in understanding the microbiome through the Oxford Centre for Microbiome Studies (OCMS).

I previously worked on a rare population of cells called innate lymphoid cells or ILCs, and how they contribute to intestinal inflammation, and before that my PhD was focused on mechanisms by which CD8+ T cells stay alive.

I also teach pathology and immunology aspects of the undergraduate medical course at Corpus Christi College and Oriel College.

Update: Induction of Inflammatory Bowel Disease in Immunodeficient Mice by Injection of Naïve CD4+ T cells (T Cell Transfer Model of Colitis).

Pearson CF. and Maloy KJ., (2024), Curr Protoc, 4

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses.

Heuberger CE. et al, (2024), Mucosal Immunol, 17, 416 - 430

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Claire Pearson

Recent publications

A concise guide to setting up a germ-free unit

Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut.

linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.

Update: Induction of Inflammatory Bowel Disease in Immunodeficient Mice by Injection of Naïve CD4+ T cells (T Cell Transfer Model of Colitis).

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses.

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Contact information

Research groups

Colleges

Claire Pearson

Recent publications

A concise guide to setting up a germ-free unit

Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut.

linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.

Update: Induction of Inflammatory Bowel Disease in Immunodeficient Mice by Injection of Naïve CD4+ T cells (T Cell Transfer Model of Colitis).

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses.