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New Research from the Kusumbe group at the Kennedy Institute of Rheumatology identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of aging and highlights organ-specific vascular changes with age.

A montage of images showing 3D scans of mouse spleens and kidneys — From left to right 1 - Tile scan 3D confocal image showing a mouse spleen with multicolour immunolabeling for endothelial cell and pericyte markers. Blue shows cell nuclei stained with TO-PRO-3. 2 - Tile scan 3D confocal image showing a mouse spleen with multicolour immunolabeling for endothelial cell and pericyte markers. 3 - Tile scan 3D confocal image showing a mouse kidney with multicolour immunolabeling for endothelial cell and pericyte markers. Blue shows cell nuclei stained with TO-PRO-3. 4 - Tile scan 3D confocal image showing a mouse kidney with multicolour immunolabeling for endothelial cell and pericyte markers.

Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

Scherlinger M. et al, (2026), J Transl Autoimmun, 12

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.

Alsaleh G. et al, (2026), Aging Cell, 25

PD-1 signaling and PD-1 blockade-mediated tumor control are established at microvillar T cell contacts.

Jenkins E. et al, (2026), Sci Immunol, 11

Prevalence of foot/ankle osteoarthritis and pain in retired male professional footballers compared to general population male controls: a cross-sectional study.

Thanoon AA. et al, (2026), Rheumatology (Oxford)

Severe menstrual pain is not normal: adolescent dysmenorrhoea as a marker of future chronic pain

Poli-Neto OB. et al, (2026), Revista Brasileira de Ginecologia e Obstetrícia, 48

Refining the Multivariable Predictive‐Prognostic PREDICTR ‐ OPC Model for Survival in Surgical Escalation for Oropharyngeal Squamous Cell Carcinoma

Zhang LL. et al, (2026), The Laryngoscope

Early plasma proteomic alterations precede amyloidosis diagnosis, reflecting cardiac and immune dysregulation

Hasheminasab SA. et al, (2026)

Long-term risk of knee replacement after ACL reconstruction using the contralateral knee as an internal control: a National Hospital Episode Statistics database study of 135 881 patients.

Hennessy C. et al, (2026), Br J Sports Med

Targeting fibroblasts in immune mediated inflammatory diseases: a cellular basis for cure?

Xenophontos M. et al, (2026), Rheumatology (Oxford)

The role of HMGB1 in myocardial infarction

Lee TY., (2026)

Identification of genetic risk loci associated with aquaporin 4-positive neuromyelitis optica spectrum disorder: a genome-wide association study.

Attfield KE. et al, (2026), Lancet Neurol, 25, 482 - 491

Reoperation in the year following a hip fracture : a nationwide cohort study in England.

Patel R. et al, (2026), Bone Joint J, 108-B, 698 - 706

Deformation-Recovery diffusion model (DRDM): Instance deformation for image manipulation and synthesis.

Zheng J-Q. et al, (2026), Med Image Anal, 110

TANK-binding kinase 1 (TBK1): unexpected cell type-specific immune regulation beyond antiviral type I interferon signaling.

Almeida MS. et al, (2026), Curr Opin Virol, 76

Resolving the mechanical paradox of myelination.

Fritzsche M., (2026), Commun Biol, 9

Metabolic profiling of steatotic liver disease by fluorescence lifetime imaging microscopy.

Purdie K. et al, (2026), Commun Med (Lond)

Hyaluronic Acid-Phosphatidylcholine Complexes as Reductionist Mimics of Extracellular Vesicle-Mediated Boundary Lubrication in Synovial Joints.

Zhu L. et al, (2026), Acta Biomater

Kv1.3 palmitoylation regulates spatial distribution and channel removal from the immunological synapse.

Navarro-Pérez M. et al, (2026), Cell Mol Life Sci

Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense.

Silvestre-Roig C. et al, (2026), Sci Immunol, 11

The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death.

Jones Evans EL. et al, (2026), Sci Immunol, 11

Search results

Showing results for

Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.

PD-1 signaling and PD-1 blockade-mediated tumor control are established at microvillar T cell contacts.

Prevalence of foot/ankle osteoarthritis and pain in retired male professional footballers compared to general population male controls: a cross-sectional study.

Severe menstrual pain is not normal: adolescent dysmenorrhoea as a marker of future chronic pain

Refining the Multivariable Predictive‐Prognostic PREDICTR ‐ OPC Model for Survival in Surgical Escalation for Oropharyngeal Squamous Cell Carcinoma

Early plasma proteomic alterations precede amyloidosis diagnosis, reflecting cardiac and immune dysregulation

Long-term risk of knee replacement after ACL reconstruction using the contralateral knee as an internal control: a National Hospital Episode Statistics database study of 135 881 patients.

Targeting fibroblasts in immune mediated inflammatory diseases: a cellular basis for cure?

The role of HMGB1 in myocardial infarction

Identification of genetic risk loci associated with aquaporin 4-positive neuromyelitis optica spectrum disorder: a genome-wide association study.

Reoperation in the year following a hip fracture : a nationwide cohort study in England.

Deformation-Recovery diffusion model (DRDM): Instance deformation for image manipulation and synthesis.

TANK-binding kinase 1 (TBK1): unexpected cell type-specific immune regulation beyond antiviral type I interferon signaling.

Resolving the mechanical paradox of myelination.

Metabolic profiling of steatotic liver disease by fluorescence lifetime imaging microscopy.

Hyaluronic Acid-Phosphatidylcholine Complexes as Reductionist Mimics of Extracellular Vesicle-Mediated Boundary Lubrication in Synovial Joints.

Kv1.3 palmitoylation regulates spatial distribution and channel removal from the immunological synapse.

Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense.

The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death.

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Find out more about the Kusumbe Group

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