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New Research from the Kusumbe group at the Kennedy Institute of Rheumatology identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of aging and highlights organ-specific vascular changes with age.

A montage of images showing 3D scans of mouse spleens and kidneys
From left to right 1 - Tile scan 3D confocal image showing a mouse spleen with multicolour immunolabeling for endothelial cell and pericyte markers. Blue shows cell nuclei stained with TO-PRO-3. 2 - Tile scan 3D confocal image showing a mouse spleen with multicolour immunolabeling for endothelial cell and pericyte markers. 3 - Tile scan 3D confocal image showing a mouse kidney with multicolour immunolabeling for endothelial cell and pericyte markers. Blue shows cell nuclei stained with TO-PRO-3. 4 - Tile scan 3D confocal image showing a mouse kidney with multicolour immunolabeling for endothelial cell and pericyte markers.

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

Vaccine LEGACY – Applying a systems based approach to accelerate vaccine development

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

New pattern-recognition receptor signalling modalities in inflammation

Microbiome metabolites as immune checkpoints

Granulopoiesis: chromatin topology and associated functions

How does ageing influence intrinsic cartilage repair in osteoarthritis?

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

How inflammatory macrophages instruct innate effector responses in the tumour microenvironment?

Engineering Resolution – mRNA targeting of chronic inflammatory disease

Investigating cross-tissue and cross-disease immune mechanisms using single-cell/spatial multiomics & machine learning/AI-powered language learning tools

Mechanical force matters in T-cell activation

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

Unraveling the intersection of immune responses in gut and cardiovascular and health

Identification of novel therapeutic pathways for lung fibrosis and repair

Microbiome metabolites as immune checkpoints

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Find out more about the Kusumbe Group

Specialized blood vessels (green/yellow) form nurturing niches for osteoprogenitor cells (white) in bone

    Kusumbe Group

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