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In this article, the clinical, angiographic, and postmortem features of unstable angina are reviewed and its pathogenesis is discussed. Coronary plaque inflammation may play a key role in the pathogenesis of unstable angina and the evidence for this assertion is examined. Finally, the therapeutic implications of the involvement of inflammation in acute coronary syndromes are outlined.

Original publication

DOI

10.1016/s0002-9149(97)00483-9

Type

Journal article

Journal

Am J Cardiol

Publication Date

04/09/1997

Volume

80

Pages

10E - 16E

Keywords

Angina, Unstable, Animals, Coronary Angiography, Cytokines, Endothelium, Vascular, Heart Diseases, Humans, Inflammation, Thrombosis