Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs.

Original publication

DOI

10.4049/jimmunol.1402584

Type

Journal article

Journal

J Immunol

Publication Date

01/11/2015

Volume

195

Pages

4257 - 4263

Keywords

Animals, Cell Lineage, Chemokines, Female, Fetus, Flow Cytometry, Humans, Immunity, Innate, Intercellular Adhesion Molecule-1, Lymph Nodes, Lymphocytes, Lymphoid Tissue, Male, Mesenchymal Stromal Cells, Mice, Transgenic, Microscopy, Confocal, RANK Ligand, Reverse Transcriptase Polymerase Chain Reaction, Stem Cell Niche, Stromal Cells, Vascular Cell Adhesion Molecule-1