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Dok proteins are adapter proteins involved in signal transduction. Several intracellular proteins expressed in lymphocytes meet the criteria of membrane-associated adapter proteins such as members of the Dok family. To understand the role and the formation of multiprotein networks involving Dok proteins in T lymphocytes, we search for potential additional members of this family. Here, we describe the two new human dok-related genes DOK4 and DOK5 and present data showing the expression of DOK4 and DOK5 genes in T cells. These genes are the orthologues of mouse Dok4 and Dok5 genes. Based on analysis of phylogenetic trees and exon/intron structure of Dok family members, DOK4 and DOK5 define a subfamily within dok genes distinct from DOK1, DOK2 and DOK3. So, Dok-4 and Dok-5 molecules constitute a new group of adapter proteins in T cells, requiring further functional analysis.

Original publication

DOI

10.1038/sj.gene.6363891

Type

Journal article

Journal

Genes Immun

Publication Date

01/2003

Volume

4

Pages

40 - 45

Keywords

Adaptor Proteins, Signal Transducing, Carrier Proteins, Gene Expression Regulation, Humans, Intracellular Signaling Peptides and Proteins, Molecular Sequence Data, Phosphoproteins, Phylogeny, T-Lymphocytes