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I was given the honor of delivering the 2015 Lifetime Membership Award lecture at the International Proteolysis Society's annual meeting held in Penang, Malaysia in October 2015. It gave me an opportunity to look back on how I started my research on matrix metalloproteinases (MMPs) and how I continued to work on these proteinases for the next 42 years. This is a series of sketches from the personal journey that I took with MMPs, starting from the purification of metalloproteinases, cloning, structural studies, then to a more recent encounter, endocytic regulation of matrix-degrading metalloproteinases.

Original publication

DOI

10.1515/hsz-2016-0169

Type

Journal article

Journal

Biol Chem

Publication Date

01/09/2016

Volume

397

Pages

805 - 813

Keywords

Biochemistry, Cartilage, Cloning, Molecular, DNA, Complementary, History, 20th Century, History, 21st Century, Humans, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases