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The effector functions of natural killer cells are regulated by activating receptors, which recognize stress-inducible ligands expressed on target cells and signal through association with signaling adaptors. Here we developed a mouse model in which a fusion of the signaling adaptor DAP10 and ubiquitin efficiently downregulated expression of the activating receptor NKG2D on the surfaces of natural killer cells. With this system, we identified coupling of the signaling pathways triggered by NKG2D and DAP10 to those initiated by the interleukin 15 receptor. We suggest that this coupling of activating receptors to other receptor systems could function more generally to regulate cell type-specific signaling events in distinct physiological contexts.

Original publication

DOI

10.1038/ni1524

Type

Journal article

Journal

Nat Immunol

Publication Date

12/2007

Volume

8

Pages

1345 - 1352

Keywords

Animals, Killer Cells, Natural, Membrane Proteins, Mice, Models, Animal, Models, Biological, NK Cell Lectin-Like Receptor Subfamily K, Receptors, Immunologic, Receptors, Interleukin-15, Receptors, Natural Killer Cell, Signal Transduction