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Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of disease-modifying drugs resulting, to a significant degree, from our incomplete understanding of the underlying molecular mechanisms of the disease. Emerging evidence points to a role of epigenetics in the pathogenesis of OA, but research in this area is still in its early stages. In order to summarize current knowledge and to facilitate the potential coordination of future research activities, the first international workshop on the epigenetics of OA was held in Amsterdam in October 2015. Recent findings on DNA methylation and hydroxymethylation, histone modifications, noncoding RNAs, and other epigenetic mechanisms were presented and discussed. The workshop demonstrated the advantage of bringing together those working in this nascent field and highlights from the event are summarized in this report in the form of summaries from invited speakers and organizers.

Original publication

DOI

10.3109/03008207.2016.1168409

Type

Journal article

Journal

Connect Tissue Res

Publication Date

01/2017

Volume

58

Pages

37 - 48

Keywords

DNA methylation, epigenetics, histones, osteoarthritis, regulatory RNAs, Animals, Congresses as Topic, Denmark, Epigenomics, Humans, Osteoarthritis