Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

Original publication

DOI

10.1038/ni1322

Type

Journal article

Journal

Nat Immunol

Publication Date

05/2006

Volume

7

Pages

517 - 523

Keywords

Animals, Cell Line, Green Fluorescent Proteins, Humans, Immunity, Innate, Influenza A virus, Killer Cells, Natural, Mice, Mice, Knockout, Natural Cytotoxicity Triggering Receptor 1, Orthomyxoviridae Infections, Receptors, Immunologic, Species Specificity, Survival Rate