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Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.

Original publication

DOI

10.1038/341619a0

Type

Journal article

Journal

Nature

Publication Date

19/10/1989

Volume

341

Pages

619 - 624

Keywords

1-Methyl-3-isobutylxanthine, Alkaloids, Antigens, Differentiation, Bucladesine, Cell Adhesion, Cell Adhesion Molecules, Colforsin, Humans, In Vitro Techniques, Lymphocyte Activation, Lymphocyte Function-Associated Antigen-1, Micelles, Phorbol Esters, Receptors, Antigen, T-Cell, Receptors, Leukocyte-Adhesion, Staurosporine, T-Lymphocytes, Temperature