Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Chemokines play an important role in establishing the distribution of lymphocyte subpopulations in primary and secondary lymphoid tissues and in the recruitment of leukocytes to sites of inflammation. However, the potential of chemokines to down-regulate immune responses has not been demonstrated. We now show that certain chemokine gradients have the potential to suppress T cell activation by preventing formation of the immunological synapse, the specialized cell-cell junction that forms before a T cell can be fully activated. Our data reveals an immunosuppressive potential of chemokines engaging the CXCR3 and CCR7 receptors, but not the CXCR4, CCR2, CCR4, or CCR5 receptors. These results suggest a novel mechanism for T cell ignorance of agonist MHC-peptide complexes based on dominant chemokine gradients.

Type

Journal article

Journal

J Immunol

Publication Date

01/07/2000

Volume

165

Pages

15 - 19

Keywords

Animals, Cell Migration Inhibition, Cell Movement, Chemokine CCL21, Chemokines, CC, Clonal Anergy, Histocompatibility Antigens Class II, Immunosuppressive Agents, Intercellular Adhesion Molecule-1, Lymphocyte Activation, Mice, Mice, Transgenic, Microscopy, Video, Muramidase, Peptide Fragments, Receptors, Antigen, T-Cell, Receptors, Chemokine, Signal Transduction, T-Lymphocyte Subsets