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The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell-cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.

Type

Journal article

Journal

J Clin Immunol

Publication Date

07/2001

Volume

21

Pages

258 - 263

Keywords

Antigen-Presenting Cells, Cell Adhesion Molecules, Cell Communication, Cell Compartmentation, Cell Division, Cell Survival, Intercellular Junctions, Lymphocyte Activation, Signal Transduction, T-Lymphocytes