Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. Speedy delivery of signals may be crucial, and membrane trafficking from endosomes and the Golgi apparatus seem to be essential in delivering the messages from spatially segregated surface receptors.

Original publication

DOI

10.1038/ni1057

Type

Journal article

Journal

Nat Immunol

Publication Date

04/2004

Volume

5

Pages

363 - 372

Keywords

Animals, Cell Adhesion, Cell Membrane, Humans, Intercellular Adhesion Molecule-1, Lymphocyte Function-Associated Antigen-1, Signal Transduction, T-Lymphocytes, rap1 GTP-Binding Proteins