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Siegelman and colleagues demonstrate unexpected synergism of CD44 and VLA-4 during lymphocyte extravasation. This is the first time that molecules mediating rolling and firm adhesion have been shown to associate biochemically leading to direct functional cooperation.

Type

Journal article

Journal

Immunity

Publication Date

04/2004

Volume

20

Pages

361 - 362

Keywords

Animals, Cell Adhesion, Humans, Hyaluronan Receptors, Inflammation, Integrin alpha4beta1, Leukocyte Rolling, T-Lymphocytes