Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The evidence for the interaction of 2 subpopulations of T cells, short-lived cells sensitive to adult thymectomy (T1 cells), and long-lived recirculating cells, sensitive to the action of antilymphocyte serum (T2 cells) in the induction of helper cells is presented. This T-T interaction occurred across a cell-impermeable nucleopore membrane, indicating that it did not depend on cell contact, but was mediated by subcellular factors. There was no genetic restriction on this T-T interaction, if it was performed across a nucleopore membrane. The implications of these results on our concepts of the mechanism of help are discussed.

Type

Journal article

Journal

Z Immunitatsforsch Immunobiol

Publication Date

09/1977

Volume

153

Pages

217 - 225

Keywords

Animals, Antilymphocyte Serum, Cell Separation, Cells, Cultured, Dinitrobenzenes, Lymphocyte Cooperation, Membranes, Artificial, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, T-Lymphocytes