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The precise role of T cells in multiple sclerosis (MS) remains to be defined. No MS-specific antigen has been found. The autoimmune hypothesis for MS rests on immune changes seen in the spinal fluid and brain and on the demonstration, in an experimental animal model, that T cells raised to myelin basic protein transfer demyelination. In this review, Virginia Calder and colleagues focus on recent studies suggesting that in MS, the initial T-cell response occurs within the central nervous system and that the blood poorly reflects this immune activity. This contrasts with the animal model, experimental allergic encephalomyelitis, where the initial immune response is peripheral.

Original publication

DOI

10.1016/0167-5699(89)90235-1

Type

Journal article

Journal

Immunol Today

Publication Date

03/1989

Volume

10

Pages

99 - 103

Keywords

Central Nervous System, Demyelinating Diseases, Encephalomyelitis, Autoimmune, Experimental, Humans, Multiple Sclerosis, Myelin Basic Protein, T-Lymphocytes