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Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated. All of these features are of importance in stem cell niches where a precise regulation of growth versus differentiation has to be guaranteed. In this review we summarize the expression and possible functions of tenascins in neural, epithelial and osteogenic stem cell niches during normal development and organ turnover, in the hematopoietic and pro-inflammatory niche as well as in the metastatic niche during cancer progression.

Original publication

DOI

10.1016/j.matbio.2014.01.007

Type

Journal article

Journal

Matrix Biol

Publication Date

07/2014

Volume

37

Pages

112 - 123

Keywords

Cancer, Development, Hematopoiesis, Inflammation, Stem cell niche, Tenascin, Cell Differentiation, Cell Movement, Gene Expression Regulation, Developmental, Hematopoietic Stem Cells, Humans, Neoplasm Metastasis, Neovascularization, Pathologic, Neural Stem Cells, Osteogenesis, Pluripotent Stem Cells, Tenascin