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The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.

Original publication

DOI

10.1101/cshperspect.a002311

Type

Journal article

Journal

Cold Spring Harb Perspect Biol

Publication Date

10/2010

Volume

2

Keywords

Animals, Cell Movement, Cell Polarity, Humans, Immunological Synapses, Lymphocyte Activation, Mice, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes