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Protein kinase C (PKC)-θ regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-θ in T cells is complex. PKC-θ plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-θ is required for the development of natural CD4(+)Foxp3(+) regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-θ in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-θ in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.

Original publication

DOI

10.1016/j.it.2011.04.007

Type

Journal article

Journal

Trends Immunol

Publication Date

08/2011

Volume

32

Pages

358 - 363

Keywords

Animals, Autoimmune Diseases, Humans, Immunological Synapses, Immunotherapy, Lymphocyte Activation, Molecular Targeted Therapy, Protein Kinase C, Receptor-CD3 Complex, Antigen, T-Cell, Signal Transduction, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory