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BACKGROUND: Delay in fracture healing is a complex clinical and economic issue for patients and health services. OBJECTIVES: To assess the incremental effectiveness and costs of bone morphogenetic protein on fracture healing in fractures and nonunions compared with standards of care. SEARCH STRATEGY: We searched The Cochrane Library (2008, Issue 4), MEDLINE, and other major health and health economics databases (to October 2008). SELECTION CRITERIA: Randomized controlled trials (RCTs) and full or partial economic evaluations of bone morphogenetic protein for fracture healing in skeletally mature adults. DATA COLLECTION AND ANALYSIS: All clinical and economic data were extracted by one author and checked by another.

Original publication




Journal article


J Hand Surg Eur Vol

Publication Date





447 - 449


Adult, Bone Morphogenetic Proteins, Fracture Healing, Humans, Randomized Controlled Trials as Topic